Stanovili sme kritickú micelovú koncentráciu (c.m.c.) derivátov typu piperidínoetylesterov 3-alkoxysubstituovaných kyselin fenylkarbámových v roztokoch 0,05 moUl a 0,2 mol/l NaCI spektroskopickou metódou v ultrafialovej (UV) oblasti pri teplote T=25 °C a pH=4,5-5,0.Podla našich zistení je závislot -ln(c.m.c.) od počtu (n) uhlíkov v alkoxysubstituente parabolická. Ďalej sme pozorovali lahšiu formáciu miciel v roztokoch 0,2 moUl ako v prípade 0,05 mol/l NaCI.

We have determined the critical micellar concentration (c.m.c) of the derivates type piperidinoethyl esters 3-alkoxy phenylcarbamic in the medium 0.05 moUl and 0.2/mol/l NaCI for using spectrophotometry methods in the UV region of the spectrum at temperature T=25 °C and pH=4.5-5.0. We found the parabolic dependence of the -ln(c.m.c.) on the (n) number of the carbon in the alkoxy substituent chain. Further, we have observed the facility formation of the micelle at the solution of 0.2 moUl than 0.05 mol/l NaCI.

Katedra farmaeutickej chémie FaF Univ Kom Bratislava

Study of local anesthetics CLX. Determination of the critical micellar concentration (c.m.c.) in series of the derivates piperidinoethylesters of 3-alkoxyphenylcarbamic acid

Štúdium lokálnych anestetík CLX. Stanovenie kritickej micelovej koncentrácie (C.M.C.) série piperidinoetylesterov 3-alkoxyfenylkarbámovej kyseliny = Study of local anesthetics CLX. Determination of the critical micellar concentration (c.m.c.) in series of the derivates piperidinoethylesters of 3-alkoxyphenylcarbamic acid /

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Souhrn: eng