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Vyprazdňování žaludku u pacientů s diabetem 2. typu a diabetem spojeným s mutací typu 3243 mitochondriální DNA za pomoci dechového testu s 13C kyselinou oktanovou
[Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test]
Sakae Nohara, Masanori Iwase, Hirofumi Imoto, Nobuhiro Sasaki, Udai Nakamura, Yuji Uchizono, Saori Abe, Yasufumi Doi, Mitsuo Iida
Jazyk čeština Země Česko
- MeSH
- dechové testy metody MeSH
- diabetes mellitus 2. typu komplikace MeSH
- diabetické neuropatie etiologie komplikace MeSH
- interpretace statistických dat MeSH
- komplikace diabetu etiologie MeSH
- lidé MeSH
- mitochondriální nemoci genetika komplikace MeSH
- průřezové studie MeSH
- vyprazdňování žaludku MeSH
- Check Tag
- lidé MeSH
Although the (13)C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing (13)C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.
Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test
Lit.: 32
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- $a Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test
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- $a Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka
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- $a Lit.: 32
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- $a Although the (13)C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing (13)C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.
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