-
Something wrong with this record ?
Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity
Urban M, Sarek J, Tislerova I, Dzubak P, Hajduch M.
Bioorganic & medicinal chemistry.
2005 ;
13 (19) :
5527-5535.
Language English Country Great Britain
Persistent link
https://www.medvik.cz/link/bmc07507039
- MeSH
- Esterification MeSH
- Financing, Organized MeSH
- Quantitative Structure-Activity Relationship MeSH
- Carboxylic Acids pharmacology chemical synthesis MeSH
- Humans MeSH
- Molecular Conformation MeSH
- Cell Line, Tumor MeSH
- Cell Proliferation drug effects MeSH
- Drug Screening Assays, Antitumor MeSH
- Triterpenes pharmacology chemical synthesis MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
The aim of this work was to find an optimal ester group for preparation of lupane derivatives connecting high cytotoxicity with good chemical and pharmacological properties. Activities of methyl-, pivaloyloxymethyl- (Pom-), and acetoxymethyl- (Acm-) esters were compared with the activity of free acids. Although the methyl- and Pom-esters were generally less active than free acids, some Acm-esters had cytotoxicity similar to or even better than the starting compounds. Cytotoxic activity was measured in five cancer cell lines.
- 000
- 02748naa 2200457 a 4500
- 001
- bmc07507039
- 003
- CZ-PrNML
- 005
- 20111210122804.0
- 008
- 080728s2005 xxk e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Urban, Milan $7 xx0117688
- 245 10
- $a Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity / $c Urban M, Sarek J, Tislerova I, Dzubak P, Hajduch M.
- 314 __
- $a Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Prague 2, Czech Republic.
- 520 9_
- $a The aim of this work was to find an optimal ester group for preparation of lupane derivatives connecting high cytotoxicity with good chemical and pharmacological properties. Activities of methyl-, pivaloyloxymethyl- (Pom-), and acetoxymethyl- (Acm-) esters were compared with the activity of free acids. Although the methyl- and Pom-esters were generally less active than free acids, some Acm-esters had cytotoxicity similar to or even better than the starting compounds. Cytotoxic activity was measured in five cancer cell lines.
- 650 _2
- $a kyseliny karboxylové $x farmakologie $x chemická syntéza $7 D002264
- 650 _2
- $a proliferace buněk $x účinky léků $7 D049109
- 650 _2
- $a triterpeny $x farmakologie $x chemická syntéza $7 D014315
- 650 _2
- $a nádorové buněčné linie $7 D045744
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a screeningové testy protinádorových léčiv $7 D004354
- 650 _2
- $a esterifikace $7 D004951
- 650 _2
- $a molekulární konformace $7 D008968
- 650 _2
- $a kvantitativní vztahy mezi strukturou a aktivitou $7 D021281
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Šarek, Jan, $d 1974- $7 uk2007350971
- 700 1_
- $a Tišlerová, Iva $7 xx0119407
- 700 1_
- $a Džubák, Petr $7 xx0080445
- 700 1_
- $a Hajdúch, Marián, $d 1969- $7 xx0050218
- 773 0_
- $w MED00000769 $t Bioorganic & medicinal chemistry $g Roč. 13, č. 19 (2005), s. 5527-5535 $x 0968-0896
- 910 __
- $a ABA008 $b x $y 9
- 990 __
- $a 20080721085927 $b ABA008
- 991 __
- $a 20081014114142 $b ABA008
- 999 __
- $a ok $b bmc $g 622647 $s 475080
- BAS __
- $a 3
- BMC __
- $a 2005 $b 13 $c 19 $d 5527-5535 $i 0968-0896 $m Bioorganic & medicinal chemistry $x MED00000769
- LZP __
- $a 2008-Doreen
