Preimplantation genetic diagnosis (PGD) abandoned the group of experimental methods and became an unreplaceable and indespensable therapeutic procedure in selected group of infertile couples. Methods: The authors reffer the group of 58 PGD cycles for the male infertility factor performed since 2004 to 2005, with the major reason being teratospermia. The control group was created of 67 cycles for PGD-AS. Fluorescent in - situ hybridization (FISH) was used to detect embryo aneuploidy (up to 8 chromosomes). Other conditions and procedures did not differ in any respect. Results: More than 60 % of preimplantation embryos in MFI group carried chromosomal abnormalities. Both the blastocyst embryotransfers ratio (65 % and 78 %) and pregnancy rates per embryotransfer (19 % and 32 %) were significantly lower compared to the control group. Conclusions: Recent advances in PGD, and the widening success to cure infertility even in couples with poor fertility prognosis bring a positive outlook for improving the results in the whole field of reproductive medicine and genetics. The future focusation for the mail factor of infertility with respect to teratospermia is essential. Number of questions arising on the MFI might lead to designing next clinical studies.

Repromeda Brno

1. mezinárodní andrologický kongres v České republice, zámek Štiřín, 23.-25.2.2006

Urologické listy, 2006, roč. 4, č. 1, s. 72