-
Je něco špatně v tomto záznamu ?
Y-chromosome microdeletions: a controversial indication for preimplantation sex selection in pairs with andrological factor of infertility
Kosarova M., Siruckova K., Maskova S., Hlinka D., Weber V., Gregor V., Sobotka V.
Status neindexováno Jazyk angličtina Země Česko
Typ dokumentu abstrakty
A genetic etiology has been proposed for some severe forms of idiopathic male infertility and a region of the Y chromosome long arm (Yq) defined AZF is thought to be critical for the regulation of spermatogenesis. To date, several genes have been identified in AZF, but the actual relationship between genotype and phenotype related to AZF deletions is not well characterized. ICSI performed using spermatozoa of this deleted patiens will invariably pass this defect onto their male offspring. PGD for sex selection of preimplantation embryos is indicated in these patients. Material and methods: 762 azoospermic and severe oligozoospermic patiens from our IVF centrum were observed. Multiplex PCR strategy, 12 STSs in AZF region was used. Results: Microdeletions in AZF region were found in 15 men. Two pairs decided for PGD sex selection. Case report is presented in the oral presentation. Conclusions: Ethical and practical aspects of PGD indication for sex selection in Y-deleted men are discussed.
3. český a mezinárodní andrologický kongres, Štiřín, 13.-15.6.2008
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07518282
- 003
- CZ-PrNML
- 005
- 20111210130437.0
- 008
- 090224s2008 xr e eng||
- 009
- PC
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Kosařová, Marcela $7 xx0122939
- 245 10
- $a Y-chromosome microdeletions: a controversial indication for preimplantation sex selection in pairs with andrological factor of infertility / $c Kosarova M., Siruckova K., Maskova S., Hlinka D., Weber V., Gregor V., Sobotka V.
- 314 __
- $a Sanatorium Pronatal, Prague
- 500 __
- $a 3. český a mezinárodní andrologický kongres, Štiřín, 13.-15.6.2008
- 520 9_
- $a A genetic etiology has been proposed for some severe forms of idiopathic male infertility and a region of the Y chromosome long arm (Yq) defined AZF is thought to be critical for the regulation of spermatogenesis. To date, several genes have been identified in AZF, but the actual relationship between genotype and phenotype related to AZF deletions is not well characterized. ICSI performed using spermatozoa of this deleted patiens will invariably pass this defect onto their male offspring. PGD for sex selection of preimplantation embryos is indicated in these patients. Material and methods: 762 azoospermic and severe oligozoospermic patiens from our IVF centrum were observed. Multiplex PCR strategy, 12 STSs in AZF region was used. Results: Microdeletions in AZF region were found in 15 men. Two pairs decided for PGD sex selection. Case report is presented in the oral presentation. Conclusions: Ethical and practical aspects of PGD indication for sex selection in Y-deleted men are discussed.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a abstrakty $7 D020504
- 700 1_
- $a Širůčková, K. $7 xx0099800
- 700 1_
- $a Mašková, Š. $7 _AN028390
- 700 1_
- $a Hlinka, Daniel $7 xx0074046
- 700 1_
- $a Weber, V. $7 _BN006684
- 700 1_
- $a Gregor, Vladimír, $7 xx0061444 $d 1950-
- 700 1_
- $a Sobotka, Vladimír, $d 1953- $7 xx0071044
- 773 0_
- $w MED00194845 $t Abstracts of the 3rd Czech and International Congress of Andrology $g Roč. 2, Suppl.1 (2008), s. 49 $x 1802-4793
- 910 __
- $a ABA008 $b B 2486 $y 9
- 990 __
- $a 20090218133734 $b ABA008
- 991 __
- $a 20090224124117 $b ABA008
- 999 __
- $a ok $b bmc $g 636094 $s 488823
- BAS __
- $a 6 $a
- BMC __
- $a 2008 $b 2 $c Suppl.1 $d 49 $i 1802-4793 $m Abstracts of the 3rd Czech and International Congress of Andrology $x MED00194845
- LZP __
- $a 2009-08/mkbi
