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Endocannabinoid system involvement in drug addiction, depression, and neurotic disorders
Vršková D.
Jazyk angličtina Země Česko
NLK
Masaryk University Scholarly Journals
od 2000 do 2010
- MeSH
- Cannabis enzymologie účinky léků MeSH
- deprese farmakoterapie prevence a kontrola MeSH
- modely u zvířat MeSH
- modulátory kanabinoidních receptorů farmakokinetika fyziologie terapeutické užití MeSH
- myši MeSH
- neurotické poruchy diagnóza prevence a kontrola MeSH
- poruchy spojené s užíváním psychoaktivních látek farmakoterapie prevence a kontrola MeSH
- receptory kanabinoidní metabolismus účinky léků MeSH
- úzkostné poruchy farmakoterapie prevence a kontrola MeSH
- Check Tag
- myši MeSH
The aim of this paper is to bring to attention recent evidence on the roles of the central endocannabinoid system in neuropsychopathological conditions such as drug dependence, depression, anxiety, and aggression. Results of pharmacological studies with cannabinoid receptor ligands in rodent behavioural models reported (behavioural sensitisation to drugs of abuse – “open-field test”, “agonistic behaviour”, “I.V. drug self-administration”; depression – “bilateral olfactory bulbectomy”, “repeated social defeat”; aggressiveness, and anxiety – “agonistic behaviour”) are expected to show in their outcomes a possibility of predicting therapeutic pharmacological intervention into the endocannabinoid system activity in the above-mentioned neuropsychiatric disorders.
Lit.: 25
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- $a The aim of this paper is to bring to attention recent evidence on the roles of the central endocannabinoid system in neuropsychopathological conditions such as drug dependence, depression, anxiety, and aggression. Results of pharmacological studies with cannabinoid receptor ligands in rodent behavioural models reported (behavioural sensitisation to drugs of abuse – “open-field test”, “agonistic behaviour”, “I.V. drug self-administration”; depression – “bilateral olfactory bulbectomy”, “repeated social defeat”; aggressiveness, and anxiety – “agonistic behaviour”) are expected to show in their outcomes a possibility of predicting therapeutic pharmacological intervention into the endocannabinoid system activity in the above-mentioned neuropsychiatric disorders.
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