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Endocannabinoid system involvement in drug addiction, depression, and neurotic disorders
Vršková D.
Language English Country Czech Republic
NLK
Masaryk University Scholarly Journals
from 2000 to 2010
- MeSH
- Cannabis enzymology drug effects MeSH
- Depression drug therapy prevention & control MeSH
- Models, Animal MeSH
- Cannabinoid Receptor Modulators pharmacokinetics physiology therapeutic use MeSH
- Mice MeSH
- Neurotic Disorders diagnosis prevention & control MeSH
- Substance-Related Disorders drug therapy prevention & control MeSH
- Receptors, Cannabinoid metabolism drug effects MeSH
- Anxiety Disorders drug therapy prevention & control MeSH
- Check Tag
- Mice MeSH
The aim of this paper is to bring to attention recent evidence on the roles of the central endocannabinoid system in neuropsychopathological conditions such as drug dependence, depression, anxiety, and aggression. Results of pharmacological studies with cannabinoid receptor ligands in rodent behavioural models reported (behavioural sensitisation to drugs of abuse – “open-field test”, “agonistic behaviour”, “I.V. drug self-administration”; depression – “bilateral olfactory bulbectomy”, “repeated social defeat”; aggressiveness, and anxiety – “agonistic behaviour”) are expected to show in their outcomes a possibility of predicting therapeutic pharmacological intervention into the endocannabinoid system activity in the above-mentioned neuropsychiatric disorders.
Lit.: 25
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- $a Endocannabinoid system involvement in drug addiction, depression, and neurotic disorders / $c Vršková D.
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- $a Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno
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- $a Lit.: 25
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- $a The aim of this paper is to bring to attention recent evidence on the roles of the central endocannabinoid system in neuropsychopathological conditions such as drug dependence, depression, anxiety, and aggression. Results of pharmacological studies with cannabinoid receptor ligands in rodent behavioural models reported (behavioural sensitisation to drugs of abuse – “open-field test”, “agonistic behaviour”, “I.V. drug self-administration”; depression – “bilateral olfactory bulbectomy”, “repeated social defeat”; aggressiveness, and anxiety – “agonistic behaviour”) are expected to show in their outcomes a possibility of predicting therapeutic pharmacological intervention into the endocannabinoid system activity in the above-mentioned neuropsychiatric disorders.
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- $a poruchy spojené s užíváním psychoaktivních látek $x farmakoterapie $x prevence a kontrola $7 D019966
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- $w MED00011244 $t Scripta medica Facultatis medicae Universitatis Brunensis Masarykianae $g Roč. 81, č. 1 (2008), s. 47-51 $x 1211-3395
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- $u http://www.med.muni.cz/biomedjournal/pdf/2008/01/47_52.pdf $y plný text volně přístupný
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