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Dynamics of PCR-based diagnosis in patients with invasive meningococcal disease
Bronska E, Kalmusova J, Dzupova O, Maresova V, Kriz P, Benes J.
Jazyk angličtina Země Francie
Typ dokumentu srovnávací studie
- MeSH
- časové faktory MeSH
- dítě MeSH
- DNA bakterií analýza genetika MeSH
- dospělí MeSH
- kojenec MeSH
- krev mikrobiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- meningokoková meningitida diagnóza MeSH
- meningokokové infekce diagnóza MeSH
- mladiství MeSH
- mozkomíšní mok mikrobiologie MeSH
- Neisseria meningitidis genetika izolace a purifikace růst a vývoj MeSH
- polymerázová řetězová reakce metody MeSH
- předškolní dítě MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
Invasive meningococcal disease continues to be a life-threatening condition and rapid diagnosis is important for the administration of appropriate treatment. This study focused on the use of PCR for the diagnosis of meningococcal aetiology and the dynamics of PCR-based diagnosis over time in various biological samples. Sixty cerebrospinal fluid (CSF) and 144 serum samples collected during the first week of hospitalisation from 37 patients with laboratory-confirmed invasive meningococcal disease were investigated. Overall, 91.9% of CSF samples and 45.9% of serum samples were PCR-positive, while culture of CSF and blood was positive for only 35% and 39% samples, respectively. Positive PCR results were obtained until day 7 with CSF and until day 5 with serum. It is therefore recommended that samples for molecular diagnosis should be collected early in the course of suspected invasive meningococcal disease.
Citace poskytuje Crossref.org
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- $a 10.1111/j.1469-0691.2005.01327.x $2 doi
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- $a Invasive meningococcal disease continues to be a life-threatening condition and rapid diagnosis is important for the administration of appropriate treatment. This study focused on the use of PCR for the diagnosis of meningococcal aetiology and the dynamics of PCR-based diagnosis over time in various biological samples. Sixty cerebrospinal fluid (CSF) and 144 serum samples collected during the first week of hospitalisation from 37 patients with laboratory-confirmed invasive meningococcal disease were investigated. Overall, 91.9% of CSF samples and 45.9% of serum samples were PCR-positive, while culture of CSF and blood was positive for only 35% and 39% samples, respectively. Positive PCR results were obtained until day 7 with CSF and until day 5 with serum. It is therefore recommended that samples for molecular diagnosis should be collected early in the course of suspected invasive meningococcal disease.
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