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Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro
Bobek V, Pinterova D, Kolostova K, Boubelik M, Douglas J, Teyssler P, Pavlasek J, Kovarik J.
Jazyk angličtina Země Irsko
Typ dokumentu srovnávací studie
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- buňky HT-29 MeSH
- časové faktory MeSH
- cisplatina farmakologie MeSH
- deoxycytidin analogy a deriváty farmakologie MeSH
- fibrinolytika farmakologie MeSH
- financování organizované MeSH
- lidé MeSH
- nádory tračníku MeSH
- proliferace buněk účinky léků účinky záření MeSH
- protinádorové látky farmakologie MeSH
- streptokinasa farmakologie MeSH
- synergismus léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy.
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- $a Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro / $c Bobek V, Pinterova D, Kolostova K, Boubelik M, Douglas J, Teyssler P, Pavlasek J, Kovarik J.
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- $a Department of Tumor Biology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 34, Czech Republic. vbobek@centrum.cz
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- $a The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy.
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