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Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro
Bobek V, Pinterova D, Kolostova K, Boubelik M, Douglas J, Teyssler P, Pavlasek J, Kovarik J.
Language English Country Ireland
Document type Comparative Study
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- HT29 Cells MeSH
- Time Factors MeSH
- Cisplatin pharmacology MeSH
- Deoxycytidine analogs & derivatives pharmacology MeSH
- Fibrinolytic Agents pharmacology MeSH
- Financing, Organized MeSH
- Humans MeSH
- Colonic Neoplasms MeSH
- Cell Proliferation drug effects radiation effects MeSH
- Antineoplastic Agents pharmacology MeSH
- Streptokinase pharmacology MeSH
- Drug Synergism MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
- Publication type
- Comparative Study MeSH
The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy.
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- $a Streptokinase increases the sensitivity of colon cancer cells to chemotherapy by gemcitabine and cis-platine in vitro / $c Bobek V, Pinterova D, Kolostova K, Boubelik M, Douglas J, Teyssler P, Pavlasek J, Kovarik J.
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- $a Department of Tumor Biology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 34, Czech Republic. vbobek@centrum.cz
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- $a The aim was to determine the effect of fybrinolytic therapy by streptokinase on chemotherapy and radiation response in human colon cancer cells. The cells were treated with different concentrations of gemcitabine, cis-platine and streptokinase, at a single use or in combinations. Radiation was tested at a dose 0.5, 5 and 15 Gy in three different schedules. The chemotherapy showed higher cytotoxic effect in combination with streptokinase. On the other hand, the combination of chemotherapy with streptokinase and radiotherapy provide no improvement in sensitivity of cancer cells to treatment. The data suggest that fybrinolytic therapy could influence the effect of chemotherapy.
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