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Mitochondrial uncoupling protein 2 gene transcript levels are elevated in maturating erythroid cells
Flachs P., Šponarová J., Kopecký P., Horváth O., Šedivá A., Nibbelink M., Casteilla L., Medříková D., Neckář J., Kolář F., Kopecký J.
Jazyk angličtina Země Nizozemsko
Typ dokumentu práce podpořená grantem
NLK
Free Medical Journals
od 1968 do 2015
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
Wiley Free Content
od 1997 do Před 1 rokem
- MeSH
- embryo savčí MeSH
- erytroidní buňky cytologie chemie MeSH
- erytropoéza genetika MeSH
- fetální krev MeSH
- játra cytologie MeSH
- lidé MeSH
- messenger RNA analýza MeSH
- myši MeSH
- proteiny analýza fyziologie genetika MeSH
- retikulocyty chemie MeSH
- stárnutí buněk genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.
Citace poskytuje Crossref.org
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- $a 10.1016/j.febslet.2007.02.012 $2 doi
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- $a Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
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- $a Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.
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