• Je něco špatně v tomto záznamu ?

Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus

K. Petrov, I. Kovyazina, V. Zobov, E. Bukharaeva, E.E. Nikolsky, F. Vyskočil

. 2009 ; 58 (1) : 149-153.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc07529058

Derivative of 6-methyluracil, selective cholinesterase inhibitor C-547 potentiates miniature endplate currents (MEPCs) in rat external intercostal muscles (external ICM) more effectively than in internal intercostal muscles (internal ICM). Effect of the C-547 on intercostal muscles was compared with those on extensor digitorum longus (EDL) and diaphragm muscles. Half-effective concentrations for tau of MEPC decay arranged in increasing order were as follows: EDL, locomotor muscle, most sensitive = 1.3 nM, external ICM, inspiration muscle = 6.8 nM, diaphragm, main inspiration muscle = 28 nM, internal ICM, expiration muscle = 71 nM. External ICM might therefore be inhibited, similarly as the limb muscles, by nanomolar concentrations of the drug and do not participate in inspiration in the presence of the C-547. Moreover, internal ICM inhibition can hinder the expiration during exercise-induced fast breathing of C-547- treated experimental animals.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 23

000      
00000naa 2200000 a 4500
001      
bmc07529058
003      
CZ-PrNML
005      
20111210145715.0
008      
090915s2009 xr e eng||
009      
AR
024    7_
$a 10.33549/physiolres.931698 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Petrov, K.
245    10
$a Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus / $c K. Petrov, I. Kovyazina, V. Zobov, E. Bukharaeva, E.E. Nikolsky, F. Vyskočil
314    __
$a A. E. Arbuzov Institute of Organic and Physical Chemistry, Russian Academy of Sciences, Kazan
504    __
$a Lit.: 23
520    9_
$a Derivative of 6-methyluracil, selective cholinesterase inhibitor C-547 potentiates miniature endplate currents (MEPCs) in rat external intercostal muscles (external ICM) more effectively than in internal intercostal muscles (internal ICM). Effect of the C-547 on intercostal muscles was compared with those on extensor digitorum longus (EDL) and diaphragm muscles. Half-effective concentrations for tau of MEPC decay arranged in increasing order were as follows: EDL, locomotor muscle, most sensitive = 1.3 nM, external ICM, inspiration muscle = 6.8 nM, diaphragm, main inspiration muscle = 28 nM, internal ICM, expiration muscle = 71 nM. External ICM might therefore be inhibited, similarly as the limb muscles, by nanomolar concentrations of the drug and do not participate in inspiration in the presence of the C-547. Moreover, internal ICM inhibition can hinder the expiration during exercise-induced fast breathing of C-547- treated experimental animals.
650    _2
$a financování organizované $7 D005381
650    _2
$a zvířata $7 D000818
650    _2
$a cholinesterasové inhibitory $x farmakologie $7 D002800
650    _2
$a bránice $x enzymologie $x účinky léků $7 D003964
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a mezižeberní svaly $x enzymologie $x účinky léků $7 D007366
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a miniaturní postsynaptické potenciály $x účinky léků $7 D055369
650    _2
$a kosterní svaly $x enzymologie $x účinky léků $7 D018482
650    _2
$a kvartérní amoniové sloučeniny $x farmakologie $7 D000644
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a mechanika dýchání $x účinky léků $7 D015656
650    _2
$a časové faktory $7 D013997
650    _2
$a uracil $x analogy a deriváty $x farmakologie $7 D014498
700    1_
$a Kovyazina, I.
700    1_
$a Zobov, V.
700    1_
$a Bukharaeva, E.
700    1_
$a Nikolsky, E. E.
700    1_
$a Vyskočil, František, $d 1941- $7 jk01151227
773    0_
$w MED00003824 $t Physiological research $g Roč. 58, č. 1 (2009), s. 149-153 $x 0862-8408
856    41
$u http://www.biomed.cas.cz/physiolres/pdf/58/58_149.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 4120 $c 266 $y 9
990    __
$a 20090910142741 $b ABA008
991    __
$a 20090915104810 $b ABA008
999    __
$a ok $b bmc $g 680104 $s 540083
BAS    __
$a 3
BMC    __
$a 2009 $b 58 $c 1 $d 149-153 $i 0862-8408 $m Physiological research $x MED00003824
LZP    __
$a 2009-31/mkme

Najít záznam

Citační ukazatele

Možnosti archivace