• Je něco špatně v tomto záznamu ?

Activation of adenosine A3 receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells

Michal Hofer, Antonín Vacek, Milan Pospíšil, Jiřina Holá, Denisa Štreitová, Vladimír Znojil

. 2009 ; 58 (2) : 247-252.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc07530711

Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro. IB-MECA alone induced no GM-CFC growth. Significant elevation of numbers of GM-CFC evoked by the combinations of IB-MECA with IL-3, SCF, or GM-CSF as compared with these growth factors alone has been noted. Combination of IB-MECA with G-CSF did not induce significantly higher numbers of GM-CFC in comparison with G-CSF alone. Joint action of three drugs, namely of IB-MECA + IL-3 + GM-CSF, produced significantly higher numbers of GM-CFC in comparison with the combinations of IB-MECA + IL-3, IB-MECA + GM-CSF, or IL-3 + GM-CSF. These results give evidence of a significant role of selective activation of adenosine A(3) receptors in stimulation of the growth of granulocyte/ macrophage hematopoietic progenitor cells.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 27

000      
00000naa 2200000 a 4500
001      
bmc07530711
003      
CZ-PrNML
005      
20111210151754.0
008      
091009s2009 xr e eng||
009      
AR
024    7_
$a 10.33549/physiolres.931454 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hofer, Michal $7 xx0074123
245    10
$a Activation of adenosine A3 receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells / $c Michal Hofer, Antonín Vacek, Milan Pospíšil, Jiřina Holá, Denisa Štreitová, Vladimír Znojil
314    __
$a Academy of Sciences of the Czech Republic, Brno
504    __
$a Lit.: 27
520    9_
$a Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro. IB-MECA alone induced no GM-CFC growth. Significant elevation of numbers of GM-CFC evoked by the combinations of IB-MECA with IL-3, SCF, or GM-CSF as compared with these growth factors alone has been noted. Combination of IB-MECA with G-CSF did not induce significantly higher numbers of GM-CFC in comparison with G-CSF alone. Joint action of three drugs, namely of IB-MECA + IL-3 + GM-CSF, produced significantly higher numbers of GM-CFC in comparison with the combinations of IB-MECA + IL-3, IB-MECA + GM-CSF, or IL-3 + GM-CSF. These results give evidence of a significant role of selective activation of adenosine A(3) receptors in stimulation of the growth of granulocyte/ macrophage hematopoietic progenitor cells.
650    _2
$a financování organizované $7 D005381
650    _2
$a adenosin $x analogy a deriváty $x farmakologie $7 D000241
650    _2
$a zvířata $7 D000818
650    _2
$a buněčné dělení $x účinky léků $7 D002455
650    _2
$a synergismus léků $7 D004357
650    _2
$a faktor stimulující granulocyto-makrofágové kolonie $x farmakologie $7 D016178
650    _2
$a granulocyty $x cytologie $7 D006098
650    _2
$a hematopoetické kmenové buňky $x cytologie $x metabolismus $x účinky léků $7 D006412
650    _2
$a hepatocytární růstový faktor $x farmakologie $7 D017228
650    _2
$a interleukin-3 $x farmakologie $7 D007377
650    _2
$a makrofágy $x cytologie $7 D008264
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a inbrední kmeny myší $7 D008815
650    _2
$a receptor adenosinový A3 $x metabolismus $7 D043684
650    _2
$a kultivované buňky $7 D002478
700    1_
$a Pospíšil, Milan, $d 1929- $7 jk01100711
700    1_
$a Holá, Jiřina $7 xx0074137
700    1_
$a Štreitová, Denisa. $7 xx0044358
700    1_
$a Znojil, Vladimír, $d 1941-2008 $7 ola2003204904
700    1_
$a Vacek, Antonín, $d 1929-2009 $7 jk01140948
773    0_
$w MED00003824 $t Physiological research $g Roč. 58, č. 2 (2009), s. 247-252 $x 0862-8408
856    41
$u http://www.biomed.cas.cz/physiolres/pdf/58/58_247.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 4120 $c 266 $y 9
990    __
$a 20091009100046 $b ABA008
991    __
$a 20100127101136 $b ABA008
999    __
$a ok $b bmc $g 689237 $s 551078
BAS    __
$a 3
BMC    __
$a 2009 $b 58 $c 2 $d 247-252 $i 0862-8408 $m Physiological research $x MED00003824
LZP    __
$a 2009-32/mkme

Najít záznam

Citační ukazatele

Možnosti archivace