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Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH
Babická, L., Ransdorfová, Š., Březinová J., Zemanová, Z., Šindelářová, L., Šišková, M., Maaloufová, J., Čermák, J., Michalová, K.
Language English Country Great Britain
Document type Historical Article
Grant support
NR7995
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Leukemia, Erythroblastic, Acute genetics pathology MeSH
- Bone Marrow Cells physiology pathology MeSH
- Chromosome Aberrations MeSH
- History, 16th Century MeSH
- Adult MeSH
- Financing, Organized MeSH
- Gene Rearrangement genetics MeSH
- In Situ Hybridization, Fluorescence MeSH
- Karyotyping MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human genetics MeSH
- Myelodysplastic Syndromes genetics pathology MeSH
- Aged MeSH
- Check Tag
- History, 16th Century MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Historical Article MeSH
We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.
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- $a Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital and 1st Faculty of Medicine of Charles University, Prague, Czech Republic. libuse.babicka@vfn.cz
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- $a We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.
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