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Genetic defects in common variable immunodeficiency
Kopecký O, Lukesová S
Jazyk angličtina Země Velká Británie
Typ dokumentu přehledy
NLK
Medline Complete (EBSCOhost)
od 2005-02-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1997-01-01 do 2012-12-31
- MeSH
- běžná variabilní imunodeficience genetika imunologie patologie MeSH
- financování organizované MeSH
- lidé MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
Common variable immunodeficiency (CVID) is the most frequent clinically manifested primary immunodeficiency. According to clinical and laboratory findings, CVID is a heterogeneous group of diseases. Recently, the defects of molecules regulating activation and terminal differentiation of B lymphocytes have been described in some patients with CVID. In this study, we show the overview of deficiencies of inducible costimulator, transmembrane activator and calcium-modulator and cytophilin ligand interactor, CD19 molecules, their genetic basis, pathogenesis and clinical manifestations.
Citace poskytuje Crossref.org
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- $a Second Department of Internal Medicine, Charles University in Prague, Faculty of Medicine, University Hospital, 500 05 Hradec Králové, Czech Republic. kopecky.otakar@fhnk.cz
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- $a Common variable immunodeficiency (CVID) is the most frequent clinically manifested primary immunodeficiency. According to clinical and laboratory findings, CVID is a heterogeneous group of diseases. Recently, the defects of molecules regulating activation and terminal differentiation of B lymphocytes have been described in some patients with CVID. In this study, we show the overview of deficiencies of inducible costimulator, transmembrane activator and calcium-modulator and cytophilin ligand interactor, CD19 molecules, their genetic basis, pathogenesis and clinical manifestations.
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