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Cardiotrophin-1 review

David Stejskal, Viktor Ruzicka

. 2008 ; 152 (1) : 9-19.

Jazyk angličtina Země Česko

Typ dokumentu přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc10009295

Background: Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Aim of our work was to describemost important of them.Methods: systematically scan of available scientifi c resources.Results: Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasmavalues are elevated in individuals with heart failure and have high diagnostic effi cacy for the heart failure. Plasma valuesare also an independent prognostic factor. Preliminary fi ndings suggest that the determination of plasma cardiotrophin-1may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 also plays animportant cardioprotective eff ect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro andin vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play also an important protectiverole in other organ systems (such as hematopoietic, neuronal, developmental).Conclusion: Cardiotrophin is a newly discovered chemokin with a lot of system eff ects and is stable in systemcirculation hence permitting its development in the routine clinical investigation.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 121

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