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Aurora kinases: structure, functions and their association with cancer
Madhu Kollareddy, Petr Dzubak, Daniella Zheleva, Marian Hajduch
Jazyk angličtina Země Česko
Typ dokumentu přehledy
NLK
Directory of Open Access Journals
od 2001
Free Medical Journals
od 1998
Medline Complete (EBSCOhost)
od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
- MeSH
- aparát dělícího vřeténka genetika imunologie MeSH
- buněčný cyklus genetika imunologie MeSH
- cytokineze genetika imunologie MeSH
- cytoskelet genetika imunologie MeSH
- imunohistochemie metody využití MeSH
- lidé MeSH
- medicína založená na důkazech MeSH
- mikrozomy imunologie MeSH
- nádory etiologie genetika imunologie MeSH
- onkogeny genetika imunologie MeSH
- protein-serin-threoninkinasy genetika imunologie klasifikace MeSH
- protinádorové látky MeSH
- regulace genové exprese u nádorů genetika imunologie MeSH
- segregace chromozomů genetika imunologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conservedserine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpointpathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases maylead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review wediscuss the biology of these kinases: structure, function, regulation and association with cancer.Methods and Results: A literature search.Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expressioncan lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one ofthe most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively ona wide range of tumor types. The clinical data are very encouraging and promising for development of novel class ofstructurally diff erent Aurora kinase inhibitors. Hopefully the Aurora kinases will be potentially useful in drug targetedcancer treatment.
Citace poskytuje Crossref.org
Lit.: 50
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- $a Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conservedserine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpointpathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases maylead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review wediscuss the biology of these kinases: structure, function, regulation and association with cancer.Methods and Results: A literature search.Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expressioncan lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one ofthe most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively ona wide range of tumor types. The clinical data are very encouraging and promising for development of novel class ofstructurally diff erent Aurora kinase inhibitors. Hopefully the Aurora kinases will be potentially useful in drug targetedcancer treatment.
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