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Aurora kinases: structure, functions and their association with cancer
Madhu Kollareddy, Petr Dzubak, Daniella Zheleva, Marian Hajduch
Language English Country Czech Republic
Document type Review
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- MeSH
- Spindle Apparatus genetics immunology MeSH
- Cell Cycle genetics immunology MeSH
- Cytokinesis genetics immunology MeSH
- Cytoskeleton genetics immunology MeSH
- Immunohistochemistry methods utilization MeSH
- Humans MeSH
- Evidence-Based Medicine MeSH
- Microsomes immunology MeSH
- Neoplasms etiology genetics immunology MeSH
- Oncogenes genetics immunology MeSH
- Protein Serine-Threonine Kinases genetics immunology classification MeSH
- Antineoplastic Agents MeSH
- Gene Expression Regulation, Neoplastic genetics immunology MeSH
- Chromosome Segregation genetics immunology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conservedserine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpointpathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases maylead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review wediscuss the biology of these kinases: structure, function, regulation and association with cancer.Methods and Results: A literature search.Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expressioncan lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one ofthe most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively ona wide range of tumor types. The clinical data are very encouraging and promising for development of novel class ofstructurally diff erent Aurora kinase inhibitors. Hopefully the Aurora kinases will be potentially useful in drug targetedcancer treatment.
References provided by Crossref.org
Lit.: 50
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- $a Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conservedserine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpointpathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases maylead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review wediscuss the biology of these kinases: structure, function, regulation and association with cancer.Methods and Results: A literature search.Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expressioncan lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one ofthe most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively ona wide range of tumor types. The clinical data are very encouraging and promising for development of novel class ofstructurally diff erent Aurora kinase inhibitors. Hopefully the Aurora kinases will be potentially useful in drug targetedcancer treatment.
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