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Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4
D Streitova, L Weiterova, M Hofer, J Hola, V Horvath, A Kozubik, V Znojil
Language English Country United States
NLK
Medline Complete (EBSCOhost)
from 2001-01-01 to 1 year ago
- MeSH
- Adenosine antagonists & inhibitors pharmacology metabolism MeSH
- Apoptosis MeSH
- Biological Transport drug effects MeSH
- Dipyridamole pharmacology MeSH
- Financing, Organized MeSH
- Phosphodiesterase Inhibitors pharmacology MeSH
- Leukemia, T-Cell pathology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents antagonists & inhibitors pharmacology metabolism MeSH
- Check Tag
- Humans MeSH
Adenosine has been observed to suppress the growth of MOLT-4 human leukemia cells in vitro. Changes in the cell cycle, especially increased percentage of cells in S phase, prolonged generation time, and induction of apoptosis at higher adenosine concentrations have been found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, reversed partially but significantly the adenosine-induced growth suppression. It follows from these results that the action of adenosine on the MOLT-4 cells comprises its cellular uptake and intracellular operation. These findings present new data on anticancer efficacy of adenosine.
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- $a Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4 / $c D Streitova, L Weiterova, M Hofer, J Hola, V Horvath, A Kozubik, V Znojil
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- $a Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. streitova@ibp.cz
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- $a Adenosine has been observed to suppress the growth of MOLT-4 human leukemia cells in vitro. Changes in the cell cycle, especially increased percentage of cells in S phase, prolonged generation time, and induction of apoptosis at higher adenosine concentrations have been found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, reversed partially but significantly the adenosine-induced growth suppression. It follows from these results that the action of adenosine on the MOLT-4 cells comprises its cellular uptake and intracellular operation. These findings present new data on anticancer efficacy of adenosine.
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