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Dipeptidyl peptidase-IV enzymatic activity bearing molecules in human brain tumors - good or evil?
P. Busek, J. Stremenova, A. Sedo
Jazyk angličtina Země Spojené státy americké
Typ dokumentu přehledy
NLK
Free Medical Journals
od 1996
- MeSH
- biologické modely MeSH
- buněčná diferenciace MeSH
- chemokin CXCL12 metabolismus MeSH
- chemokiny metabolismus MeSH
- dipeptidylpeptidasa 4 metabolismus MeSH
- financování organizované MeSH
- glioblastom metabolismus MeSH
- gliom enzymologie metabolismus MeSH
- lidé MeSH
- mozek metabolismus MeSH
- nádory mozku enzymologie metabolismus MeSH
- proteasy metabolismus MeSH
- receptory CXCR4 metabolismus MeSH
- regulace genové exprese enzymů MeSH
- regulace genové exprese u nádorů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Dipeptidyl peptidase-IV (DPP-IV) represents a unique proteolytic activity cleaving N-terminal X-Pro dipeptides. In addition to canonical DPP-IV/CD26, a number of other molecules have been discovered which exhibit DPP-IV-like enzymatic activity and various degree of structural similarity. These comprise enzymatically active fibroblast activation protein-alpha, DPP-II, DPP8, DPP9 and enzymatically inactive DPP6 and DPP10 that have been grouped as "DPP-IV activity and/or structure homologues" (DASH). Because the enzymatically active DASH can share similar sets of biologically active substrates and are frequently coexpressed within single cell or on tissue level, it is tempting to consider their participation on biological function(s) previously attributed to DPP-IV/CD26. It is speculated that disrupted expression and enzymatic activity of some DASH might corrupt the message carried by their substrates, with consequent promotion of abnormal cell behavior. Thus, modulation of activity of a particular enzyme using e.g. inhibitors, specific antibodies or modifying its expression may be an attractive therapeutic concept in cancer treatment. This review summarizes current knowledge of the expression and possible function of DPP-IV enzymatic activity bearing molecules in human brain tumors.
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