-
Something wrong with this record ?
Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57BL/6 and NMRI mice
R. Matyšková, L. Maletínská, J. Maixnerová, Z. Pirník, A. Kiss, B. Železná
Language English Country Czech Republic
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- Keywords
- C57BL/6, NMRI, Mouse, Monosodium glutamate obesity, Diet-inducet obesity,
- MeSH
- Adiposity MeSH
- Dietary Fats MeSH
- Species Specificity MeSH
- Phenotype MeSH
- Financing, Organized MeSH
- Sodium Glutamate MeSH
- Insulin blood MeSH
- Insulin Resistance MeSH
- Blood Glucose metabolism MeSH
- Leptin blood MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Disease Susceptibility MeSH
- Animals, Newborn MeSH
- Arcuate Nucleus of Hypothalamus metabolism physiopathology MeSH
- Obesity etiology metabolism physiopathology MeSH
- Eating MeSH
- Body Weight MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
In this study, susceptibility of inbred C57BL/6 and outbred NMRI mice to monosodium glutamate (MSG) obesity or diet-induced obesity (DIO) was compared in terms of food intake, body weight, adiposity as well as leptin, insulin and glucose levels. MSG obesity is an early-onset obesity resulting from MSGinduced lesions in arcuate nucleus to neonatal mice. Both male and female C57BL/6 and NMRI mice with MSG obesity did not differ in body weight from their lean controls, but had dramatically increased fat to body weight ratio. All MSG obese mice developed severe hyperleptinemia, more remarkable in females, but only NMRI male mice showed massive hyperinsulinemia and an extremely high HOMA index that pointed to development of insulin resistance. Diet-induced obesity is a late-onset obesity; it developed during 16-week-long feeding with high-fat diet containing 60 % calories as fat. Inbred C57BL/6 mice, which are frequently used in DIO studies, both male and female, had significantly increased fat to body weight ratio and leptin and glucose levels compared with their appropriate lean controls, but only female C57BL/6 mice had also significantly elevated body weight and insulin level. NMRI mice were less prone to DIO than C57BL/6 ones and did not show significant changes in metabolic parameters after feeding with high-fat diet.
References provided by Crossref.org
Lit.: 27
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10015695
- 003
- CZ-PrNML
- 005
- 20111210180546.0
- 008
- 100726s2008 xr e eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.931274 $2 doi
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Matyšková, Resha, $d 1982- $7 xx0080233
- 245 10
- $a Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57BL/6 and NMRI mice / $c R. Matyšková, L. Maletínská, J. Maixnerová, Z. Pirník, A. Kiss, B. Železná
- 314 __
- $a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
- 504 __
- $a Lit.: 27
- 520 9_
- $a In this study, susceptibility of inbred C57BL/6 and outbred NMRI mice to monosodium glutamate (MSG) obesity or diet-induced obesity (DIO) was compared in terms of food intake, body weight, adiposity as well as leptin, insulin and glucose levels. MSG obesity is an early-onset obesity resulting from MSGinduced lesions in arcuate nucleus to neonatal mice. Both male and female C57BL/6 and NMRI mice with MSG obesity did not differ in body weight from their lean controls, but had dramatically increased fat to body weight ratio. All MSG obese mice developed severe hyperleptinemia, more remarkable in females, but only NMRI male mice showed massive hyperinsulinemia and an extremely high HOMA index that pointed to development of insulin resistance. Diet-induced obesity is a late-onset obesity; it developed during 16-week-long feeding with high-fat diet containing 60 % calories as fat. Inbred C57BL/6 mice, which are frequently used in DIO studies, both male and female, had significantly increased fat to body weight ratio and leptin and glucose levels compared with their appropriate lean controls, but only female C57BL/6 mice had also significantly elevated body weight and insulin level. NMRI mice were less prone to DIO than C57BL/6 ones and did not show significant changes in metabolic parameters after feeding with high-fat diet.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a adipozita $7 D050154
- 650 _2
- $a věkové faktory $7 D000367
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a novorozená zvířata $7 D000831
- 650 _2
- $a nucleus arcuatus hypothalami $x metabolismus $x patofyziologie $7 D001111
- 650 _2
- $a krevní glukóza $x metabolismus $7 D001786
- 650 _2
- $a tělesná hmotnost $7 D001835
- 650 _2
- $a dietní tuky $7 D004041
- 650 _2
- $a modely nemocí na zvířatech $7 D004195
- 650 _2
- $a náchylnost k nemoci $7 D004198
- 650 _2
- $a přijímání potravy $7 D004435
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a inzulin $x krev $7 D007328
- 650 _2
- $a inzulinová rezistence $7 D007333
- 650 _2
- $a leptin $x krev $7 D020738
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši inbrední C57BL $7 D008810
- 650 _2
- $a obezita $x etiologie $x metabolismus $x patofyziologie $7 D009765
- 650 _2
- $a fenotyp $7 D010641
- 650 _2
- $a glutamát sodný $7 D012970
- 650 _2
- $a druhová specificita $7 D013045
- 653 00
- $a C57BL/6
- 653 00
- $a NMRI
- 653 00
- $a Mouse
- 653 00
- $a Monosodium glutamate obesity
- 653 00
- $a Diet-inducet obesity
- 700 1_
- $a Maletínská, Lenka, $d 1965- $7 xx0080235
- 700 1_
- $a Maixnerová, Jana, $d 1980- $7 xx0080234
- 700 1_
- $a Pirník, Zdenko $7 xx0170306
- 700 1_
- $a Kiss, Alexander. $7 _AN038558
- 700 1_
- $a Železná, Blanka. $7 xx0206931
- 773 0_
- $w MED00003824 $t Physiological research $g Roč. 57, č. 5 (2008), s. 727-734 $x 0862-8408
- 856 41
- $u http://www.biomed.cas.cz/physiolres/pdf/57/57_727.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 4120 $c 266 $y 8
- 990 __
- $a 20100708110758 $b ABA008
- 991 __
- $a 20100810151343 $b ABA008
- 999 __
- $a ok $b bmc $g 756110 $s 619891
- BAS __
- $a 3
- BMC __
- $a 2008 $b 57 $c 5 $m Physiological research $x MED00003824 $d 727-734
- LZP __
- $a 2010-32/vtme