-
Je něco špatně v tomto záznamu ?
Regulatory T cells (Treg) and their roles in immune system with respect to immunopathological disorders
Kateřina Kondělková, Doris Vokurková, Jan Krejsek, Lenka Borská, Zdeněk Fiala, Ctirad Andrýs
Jazyk angličtina Země Česko
Typ dokumentu přehledy
Digitální knihovna NLK
Plný text - Článek
Číslo
Ročník
Zdroj
Zdroj
NLK
Directory of Open Access Journals
od 1997
Free Medical Journals
od 1997
Open Access Digital Library
od 1997-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1997
- Klíčová slova
- Regulatory T cells, Immunopathology, Regulation,
- MeSH
- autoimunitní nemoci imunologie MeSH
- autotolerance imunologie MeSH
- CD4-pozitivní T-lymfocyty imunologie MeSH
- financování organizované MeSH
- nemoci imunitního systému imunologie MeSH
- podskupiny lymfocytů MeSH
- průtoková cytometrie MeSH
- regulační T-lymfocyty imunologie MeSH
- Publikační typ
- přehledy MeSH
Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a critical role in preventing autoimmunity. Different subsets with various functions of Treg cells exist. Tregs can be usually identified by flow cytometry. The most specific marker for these cells is FoxP3, which is localized intracellulary. Selected surface markers such as CD25high (high molecular density) and CD127low (low molecular density) could serve as surrogate markers to detect Tregs in a routine clinical practice. Dysregulation in Treg cell frequency or functions may lead to the development of autoimmune disease. Therapeutical Treg modulation is considered to be a promising therapeutical approach to treat some selected disorders, such as allergies, and to prevent allograft rejection.
Citace poskytuje Crossref.org
Lit.: 38
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10016142
- 003
- CZ-PrNML
- 005
- 20111210182200.0
- 008
- 100726s2010 xr e eng||
- 009
- AR
- 024 7_
- $a 10.14712/18059694.2016.63 $2 doi
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Kondělková, Kateřina. $7 _AN048795
- 245 10
- $a Regulatory T cells (Treg) and their roles in immune system with respect to immunopathological disorders / $c Kateřina Kondělková, Doris Vokurková, Jan Krejsek, Lenka Borská, Zdeněk Fiala, Ctirad Andrýs
- 314 __
- $a Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Králové
- 504 __
- $a Lit.: 38
- 520 9_
- $a Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a critical role in preventing autoimmunity. Different subsets with various functions of Treg cells exist. Tregs can be usually identified by flow cytometry. The most specific marker for these cells is FoxP3, which is localized intracellulary. Selected surface markers such as CD25high (high molecular density) and CD127low (low molecular density) could serve as surrogate markers to detect Tregs in a routine clinical practice. Dysregulation in Treg cell frequency or functions may lead to the development of autoimmune disease. Therapeutical Treg modulation is considered to be a promising therapeutical approach to treat some selected disorders, such as allergies, and to prevent allograft rejection.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a autoimunitní nemoci $x imunologie $7 D001327
- 650 _2
- $a CD4-pozitivní T-lymfocyty $x imunologie $7 D015496
- 650 _2
- $a průtoková cytometrie $7 D005434
- 650 _2
- $a nemoci imunitního systému $x imunologie $7 D007154
- 650 _2
- $a podskupiny lymfocytů $7 D016131
- 650 _2
- $a autotolerance $x imunologie $7 D017634
- 650 _2
- $a regulační T-lymfocyty $x imunologie $7 D050378
- 653 00
- $a Regulatory T cells
- 653 00
- $a Immunopathology
- 653 00
- $a Regulation
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Vokurková, Doris, $7 xx0110367 $d 1958-
- 700 1_
- $a Krejsek, Jan, $d 1958- $7 nlk19990073429
- 700 1_
- $a Borská, Lenka $7 nlk20060173900
- 700 1_
- $a Fiala, Zdeněk, $d 1955- $7 nlk19990073147
- 700 1_
- $a Andrýs, Ctirad, $d 1962- $7 mzk2008430528
- 773 0_
- $w MED00010947 $t Acta medica (Hradec Králové) $g Roč. 53, č. 2 (2010), s. 73-77 $x 1211-4286
- 856 41
- $u https://actamedica.lfhk.cuni.cz/media/pdf/am_2010053020073.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 3077 $c 1072 $y 8
- 990 __
- $a 20100611141136 $b ABA008
- 991 __
- $a 20111101114355 $b ABA008
- 999 __
- $a ok $b bmc $g 765171 $s 629030
- BAS __
- $a 3
- BMC __
- $a 2010 $b 53 $c 2 $d 73-77 $m Acta Medica $x MED00010947
- LZP __
- $a 2010-20/mkme
