Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients

J.A. Hubáček, S. Bloudíčková, R. Bohuslavová, P. Táborský, V. Polakovič, M. Sazamova, E. Svítilová, J. Vlasák, I. Sojková, M. Ryba, P. Knetl, M. Ullrych, R. Drahozal, V. Pavukova, B. Pavlíková, D. Fischlová, M. Mokrejšová, H. Chmelíčková, E....

. 2007 ; 45 (9) : 1121-1123.

Jazyk angličtina Země Německo

Perzistentní odkaz   https://www.medvik.cz/link/bmc10026756

Grantová podpora
NR7958 MZ0 CEP - Centrální evidence projektů

BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications. METHODS: Ghrelin variants Arg51>Gln and Leu72> Met were analyzed by PCR-RFLP in 210 hemodialyzed patients, prospectively followed up for 15 months. Changes in body mass index, triglycerides, total cholesterol and albumin over time (after 3, 6, 9, 12 and 15 months of dialysis) were analyzed in subgroups divided according to ghrelin genotypes. RESULTS: Carriers of at least one of the Gln51 and Met72 alleles lost body weight more quickly than Arg51Arg/Leu72Leu homozygotes (p<0.01). Carriers of the Gln51 allele were at higher risk of developing high cholesterol levels (p<0.01). CONCLUSIONS: Common ghrelin variants may have an effect on changes in biochemical and anthropometric parameters in hemodialyzed patients over time and could be used in the future to plan individualized therapy.

Citace poskytuje Crossref.org

000      
00000naa 2200000 a 4500
001      
bmc10026756
003      
CZ-PrNML
005      
20240814141036.0
008      
101019s2007 gw e eng||
009      
AR
024    __
$a 10.1515/cclm.2007.141 $2 doi
035    __
$a (PubMed)17635077
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Hubáček, Jaroslav, $d 1966- $7 nlk20050169367
245    10
$a Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients / $c J.A. Hubáček, S. Bloudíčková, R. Bohuslavová, P. Táborský, V. Polakovič, M. Sazamova, E. Svítilová, J. Vlasák, I. Sojková, M. Ryba, P. Knetl, M. Ullrych, R. Drahozal, V. Pavukova, B. Pavlíková, D. Fischlová, M. Mokrejšová, H. Chmelíčková, E. Pauchová, P. Vyskočil, Z. Nydlová, J. Kopenec, P. Fixa, J. Hajny, P. Bubenicek, P. Syrovatka, J. Zahalková, S. Surel, Z. Hobzek, A. Hrubý, J. Suchanová, S. Vanková, J. Brabcová, O. Viklický, Group MIA
314    __
$a Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jahb@medicon.cz
520    9_
$a BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications. METHODS: Ghrelin variants Arg51>Gln and Leu72> Met were analyzed by PCR-RFLP in 210 hemodialyzed patients, prospectively followed up for 15 months. Changes in body mass index, triglycerides, total cholesterol and albumin over time (after 3, 6, 9, 12 and 15 months of dialysis) were analyzed in subgroups divided according to ghrelin genotypes. RESULTS: Carriers of at least one of the Gln51 and Met72 alleles lost body weight more quickly than Arg51Arg/Leu72Leu homozygotes (p<0.01). Carriers of the Gln51 allele were at higher risk of developing high cholesterol levels (p<0.01). CONCLUSIONS: Common ghrelin variants may have an effect on changes in biochemical and anthropometric parameters in hemodialyzed patients over time and could be used in the future to plan individualized therapy.
650    _2
$a alely $7 D000483
650    _2
$a arginin $x chemie $7 D001120
650    _2
$a index tělesné hmotnosti $7 D015992
650    _2
$a cholesterol $x krev $7 D002784
650    _2
$a dialýza $7 D003956
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genetická variace $7 D014644
650    _2
$a ghrelin $x biosyntéza $x genetika $x metabolismus $7 D054439
650    _2
$a glutamin $7 D005973
650    _2
$a heterozygot $7 D006579
650    _2
$a lidé $7 D006801
650    _2
$a renální insuficience $x genetika $x terapie $7 D051437
650    _2
$a leucin $x chemie $7 D007930
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a methionin $x chemie $7 D008715
650    _2
$a dialýza ledvin $7 D006435
650    _2
$a financování organizované $7 D005381
700    1_
$a Rajnochová-Bloudíčková, Silvie. $7 xx0175686
700    1_
$a Bohuslavová, Romana, $d 1966- $7 xx0074151
700    1_
$a Táborský, Petr $7 xx0077740
700    1_
$a Polakovič, Vladimír, $d 1960- $7 nlk20010095508
700    1_
$a Sazamová, Magda $7 xx0128462
700    1_
$a Svítilová, Eva $7 _AN054724
700    1_
$a Vlasák, Jiří $7 xx0122521
700    1_
$a Sojková, Iva $7 _AN054725
700    1_
$a Ryba, Miroslav $7 xx0244282
700    1_
$a Knetl, Petr $7 xx0121634
700    1_
$a Ullrych, Martin $7 xx0136963
700    1_
$a Drahozal, Radim $7 xx0320781
700    1_
$a Pavuková, Veronika $7 _AN054728
700    1_
$a Pavlíková, Beata $7 xx0128327
700    1_
$a Fischlová, Drahomíra $7 xx0074798
700    1_
$a Mokrejšová, Magdaléna $7 xx0121614
700    1_
$a Chmelíčková, Hana $7 _AN054730
700    1_
$a Pauchová, Eva $7 xx0121615
700    1_
$a Vyskočil, Pavel $7 xx0126250
700    1_
$a Nýdlová, Zuzana. $7 _AN054731
700    1_
$a Kopenec, J
700    1_
$a Fixa, P
700    1_
$a Hajny, J
700    1_
$a Bubenicek, P
700    1_
$a Syrovatka, P
700    1_
$a Zahalkova, J
700    1_
$a Surel, S
700    1_
$a Hobzek, Z
700    1_
$a Hruby, A
700    1_
$a Suchanova, J
700    1_
$a Vankova, S
700    1_
$a Brabcova, J
700    1_
$a Viklicky, O
700    1_
$a MIA, Group
773    0_
$w MED00010886 $t Clinical chemistry and laboratory medicine $g Roč. 45, č. 9 (2007), s. 1121-1123 $x 1434-6621
910    __
$a ABA008 $b x $y 7 $z 0
990    __
$a 20101031071455 $b ABA008
991    __
$a 20240814141031 $b ABA008
999    __
$a ok $b bmc $g 801861 $s 666620
BAS    __
$a 3
BMC    __
$a 2007 $b 45 $c 9 $d 1121-1123 $i 1434-6621 $m Clinical chemistry and laboratory medicine $n Clin Chem Lab Med $x MED00010886
GRA    __
$a NR7958 $p MZ0
LZP    __
$a 2010-B3/vtme

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace