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The effect of flavonoid derivatives on doxorubicin transport and metabolism
R Vaclavikova, E Kondrova, M Ehrlichova, A Boumendjel, J Kovar, P Stopka, P Soucek, I Gut
Jazyk angličtina Země Velká Británie
Grantová podpora
NR9426
MZ0
CEP - Centrální evidence projektů
- MeSH
- benzofurany farmakologie MeSH
- biologický transport účinky léků MeSH
- doxorubicin analogy a deriváty farmakokinetika metabolismus MeSH
- financování organizované MeSH
- flavonoidy farmakologie MeSH
- lidé MeSH
- metabolismus účinky léků MeSH
- nádorové buněčné linie MeSH
- nádory prsu MeSH
- protinádorová antibiotika MeSH
- quercetin farmakologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
Citace poskytuje Crossref.org
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- $a This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
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