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The effect of flavonoid derivatives on doxorubicin transport and metabolism
R Vaclavikova, E Kondrova, M Ehrlichova, A Boumendjel, J Kovar, P Stopka, P Soucek, I Gut
Language English Country Great Britain
Grant support
NR9426
MZ0
CEP Register
- MeSH
- Benzofurans pharmacology MeSH
- Biological Transport drug effects MeSH
- Doxorubicin analogs & derivatives pharmacokinetics metabolism MeSH
- Financing, Organized MeSH
- Flavonoids pharmacology MeSH
- Humans MeSH
- Metabolism drug effects MeSH
- Cell Line, Tumor MeSH
- Breast Neoplasms MeSH
- Antibiotics, Antineoplastic MeSH
- Quercetin pharmacology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
References provided by Crossref.org
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- $a This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
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