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Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers
M Novotny, A Hrabalek, B Janusova, J Novotny, K Vavrova
Bioorganic & medicinal chemistry letters.
2009 ;
19 (2) :
344-347.
Language English Country Great Britain
Persistent link
https://www.medvik.cz/link/bmc11006135
- MeSH
- Esters MeSH
- Financing, Organized MeSH
- Isomerism MeSH
- Skin Absorption drug effects MeSH
- Dicarboxylic Acids pharmacology chemistry MeSH
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.
References provided by Crossref.org
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