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Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
D Pelclova, Z Fenclova, P Kacer, M Kuzma, T Navratil, J Lebedova
Jazyk angličtina Země Japonsko
Typ dokumentu práce podpořená grantem
Grantová podpora
NR9338
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
Free Medical Journals
od 1962
J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - English
od 1963
J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - English
od 1963
Open Access Digital Library
od 1963-01-01
- MeSH
- azbest metabolismus otrava MeSH
- azbestóza metabolismus MeSH
- biologické markery analýza MeSH
- dechové testy metody MeSH
- dinoprost analogy a deriváty analýza metabolismus MeSH
- hodnocení rizik MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidační stres MeSH
- pracovní expozice MeSH
- prognóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
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- $a Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure / $c D Pelclova, Z Fenclova, P Kacer, M Kuzma, T Navratil, J Lebedova
- 314 __
- $a 1st Medical Faculty, Department of Occupational Medicine, Charles University of Prague, Prague, Czech Republic.
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- $a Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
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