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Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study
Z. Hájek, A. Germanová, M. Koucký, T. Zima, P. Kopecký, M. Vítková, A. Pařízek, M. Kalousová
Language English Country Germany
Document type Research Support, Non-U.S. Gov't
- MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Pregnancy Complications, Infectious blood MeSH
- Interleukin-6 blood MeSH
- Humans MeSH
- Pilot Projects MeSH
- Obstetric Labor, Premature blood MeSH
- Fetal Membranes, Premature Rupture blood MeSH
- Glycation End Products, Advanced blood MeSH
- Receptors, Immunologic blood MeSH
- Pregnancy MeSH
- Inflammation blood MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation end products, is an inhibitor of the pathological effect mediated via RAGE. The aim of this study was to assess the usefulness of measuring sRAGE concentration in pregnant women with threatening preterm labor. METHODS: Serum levels of sRAGE, interleukin-6 (IL-6) and routine markers of inflammation were determined in 46 pregnant women with threatening preterm labor, 35 healthy pregnant women and 15 non-pregnant controls. RESULTS: Serum levels of sRAGE in healthy pregnant women were significantly lower than in non-pregnant controls (669+/-296 vs. 1929+/-727 pg/mL, P<0.05). Women with threatening preterm birth had a significantly higher concentration of serum sRAGE in comparison with healthy pregnant women (819+/-329 pg/mL vs. 669+/-296 pg/mL, P<0.05). Conversely, patients with PPROM had significantly lower levels of sRAGE compared with patients with threatening premature labor (600+/-324 pg/mL, P<0.05). sRAGE correlated negatively with leukocyte counts (r=-0.325, P<0.05). CONCLUSIONS: sRAGE might be a new and promising marker of premature labor, especially with the symptoms of PPROM.
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- $a Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study / $c Z. Hájek, A. Germanová, M. Koucký, T. Zima, P. Kopecký, M. Vítková, A. Pařízek, M. Kalousová
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- $a Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. hajekz@vfn.cz
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- $a OBJECTIVE: The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation end products, is an inhibitor of the pathological effect mediated via RAGE. The aim of this study was to assess the usefulness of measuring sRAGE concentration in pregnant women with threatening preterm labor. METHODS: Serum levels of sRAGE, interleukin-6 (IL-6) and routine markers of inflammation were determined in 46 pregnant women with threatening preterm labor, 35 healthy pregnant women and 15 non-pregnant controls. RESULTS: Serum levels of sRAGE in healthy pregnant women were significantly lower than in non-pregnant controls (669+/-296 vs. 1929+/-727 pg/mL, P<0.05). Women with threatening preterm birth had a significantly higher concentration of serum sRAGE in comparison with healthy pregnant women (819+/-329 pg/mL vs. 669+/-296 pg/mL, P<0.05). Conversely, patients with PPROM had significantly lower levels of sRAGE compared with patients with threatening premature labor (600+/-324 pg/mL, P<0.05). sRAGE correlated negatively with leukocyte counts (r=-0.325, P<0.05). CONCLUSIONS: sRAGE might be a new and promising marker of premature labor, especially with the symptoms of PPROM.
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