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Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects

M. Meloun, M. Hill, H. Včeláková-Havlíková

. 2009 ; 47 (4) : 464-470.

Jazyk angličtina Země Německo

Perzistentní odkaz   https://www.medvik.cz/link/bmc11009495

BACKGROUND: Pregnenolone sulfate (PregS) is known as a steroid conjugate positively modulating N-methyl-D-aspartate receptors on neuronal membranes. These receptors are responsible for permeability of calcium channels and activation of neuronal function. Neuroactivating effect of PregS is also exerted via non-competitive negative modulation of GABA(A) receptors regulating the chloride influx. Recently, a penetrability of blood-brain barrier for PregS was found in rat, but some experiments in agreement with this finding were reported even earlier. It is known that circulating levels of PregS in human are relatively high depending primarily on age and adrenal activity.

Citace poskytuje Crossref.org

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