-
Je něco špatně v tomto záznamu ?
New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution
P. Kolenko, J. Dohnálek, J. Dušková, T. Skálová, R. Collard, J. Hašek
Jazyk angličtina Země Velká Británie
NLK
Free Medical Journals
od 1958 do Před 1 rokem
PubMed Central
od 1958 do 2021
Medline Complete (EBSCOhost)
od 1958-01-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1996-01-01 do 2012-12-31
Wiley Free Content
od 1996 do Před 1 rokem
- MeSH
- financování organizované MeSH
- glykosylace MeSH
- imunoglobulin G chemie MeSH
- imunoglobuliny - Fc fragmenty chemie MeSH
- imunokomplex chemie MeSH
- krystalizace MeSH
- krystalografie rentgenová metody MeSH
- monoklonální protilátky chemie MeSH
- myši MeSH
- oligosacharidy chemie MeSH
- sekundární struktura proteinů MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
The structure of the Fc fragment of monoclonal antibody IgG2b from hybridom M75 of Mus musculus has been determined by single crystal X-ray diffraction. This is the first report of the structure of the murine immunoglobulin isotype IgG2b. The structure refined at 2.1 A resolution provides more detailed structural information about native oligosaccharides than was previously available. High-quality Fourier maps provide a clear identification of alpha-l-fucose with partial occupancy in the first branch of the antennary oligosaccharides. A unique Fc:Fc interaction was observed at the C(H)2-C(H)3 interface.
Citace poskytuje Crossref.org
- 000
- 02133naa 2200397 a 4500
- 001
- bmc11009513
- 003
- CZ-PrNML
- 005
- 20221005114224.0
- 008
- 110510s2009 xxk e eng||
- 009
- AR
- 024 7_
- $a 10.1111/j.1365-2567.2008.02904.x $2 doi
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Kolenko, Petr $7 xx0124748
- 245 10
- $a New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution / $c P. Kolenko, J. Dohnálek, J. Dušková, T. Skálová, R. Collard, J. Hašek
- 314 __
- $a Department of Structure Analysis, Institute of Macromolecular Chemistry AS CR, Praha, Czech Republic. hasek@imc.cas.cz
- 520 9_
- $a The structure of the Fc fragment of monoclonal antibody IgG2b from hybridom M75 of Mus musculus has been determined by single crystal X-ray diffraction. This is the first report of the structure of the murine immunoglobulin isotype IgG2b. The structure refined at 2.1 A resolution provides more detailed structural information about native oligosaccharides than was previously available. High-quality Fourier maps provide a clear identification of alpha-l-fucose with partial occupancy in the first branch of the antennary oligosaccharides. A unique Fc:Fc interaction was observed at the C(H)2-C(H)3 interface.
- 590 __
- $a bohemika - dle Pubmed
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a monoklonální protilátky $x chemie $7 D000911
- 650 _2
- $a imunokomplex $x chemie $7 D000936
- 650 _2
- $a krystalizace $7 D003460
- 650 _2
- $a krystalografie rentgenová $x metody $7 D018360
- 650 _2
- $a glykosylace $7 D006031
- 650 _2
- $a imunoglobuliny - Fc fragmenty $x chemie $7 D007141
- 650 _2
- $a imunoglobulin G $x chemie $7 D007074
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a oligosacharidy $x chemie $7 D009844
- 650 _2
- $a sekundární struktura proteinů $7 D017433
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Dohnálek, Jan $7 xx0063750
- 700 1_
- $a Dušková, Jarmila. $7 xx0314967
- 700 1_
- $a Skálová, Tereza $7 xx0119192
- 700 1_
- $a Collard, Renata
- 700 1_
- $a Hašek, Jindřich, $d 1946- $7 mzk2006331646
- 773 0_
- $t Immunology $w MED00009850 $g Roč. 126, č. 3 (2009), s. 378-385
- 910 __
- $a ABA008 $b x $y 2 $z 0
- 990 __
- $a 20110513105835 $b ABA008
- 991 __
- $a 20221005114220 $b ABA008
- 999 __
- $a ok $b bmc $g 839060 $s 702900
- BAS __
- $a 3
- BMC __
- $a 2009 $b 126 $c 3 $d 378-385 $m Immunology $n Immunology $x MED00009850
- LZP __
- $a 2011-2B09/jvme
