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Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody
T. Jirásek, Š. Cipro, A. Musilová, M. Kubecová, V. Mandys
Language English Country India
NLK
Free Medical Journals
from 2006
Freely Accessible Science Journals
from 2006
MedKnow Publications
from 2006
Open Access Digital Library
from 2003-01-01
Medline Complete (EBSCOhost)
from 2008-02-01
- MeSH
- Adult MeSH
- Financing, Organized MeSH
- Immunohistochemistry MeSH
- Colorectal Neoplasms metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Antibodies, Monoclonal metabolism MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Tubulin metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
BACKGROUND & OBJECTIVE: Expression of class III beta-tubulin represents newly discovered marker of resistance to taxol-based chemotherapy in a wide spectra of carcinomas. However, very little is known about its expression in colorectal carcinomas. This study was done to determine class III beta-tubulin expression in a large series of colonic carcinomas, covering tumours with different degree of differentiation in order to evaluate its prospective significance in resistance to taxol-based chemotherapeutics and to compare the immunostaining profile of two widely used monoclonal antibodies, TU-20 and TuJ-1
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- $a Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody / $c T. Jirásek, Š. Cipro, A. Musilová, M. Kubecová, V. Mandys
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- $a Department of Pathology, 3rd Faculty of Medicine, Charles University Prague, Czech Republic. tjirasek@fnkv.cz
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- $a BACKGROUND & OBJECTIVE: Expression of class III beta-tubulin represents newly discovered marker of resistance to taxol-based chemotherapy in a wide spectra of carcinomas. However, very little is known about its expression in colorectal carcinomas. This study was done to determine class III beta-tubulin expression in a large series of colonic carcinomas, covering tumours with different degree of differentiation in order to evaluate its prospective significance in resistance to taxol-based chemotherapeutics and to compare the immunostaining profile of two widely used monoclonal antibodies, TU-20 and TuJ-1
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- $t Indian Journal of Medical Research $w MED00011742 $g Roč. 129, č. 1 (2009), s. 89-94 $x 0971-5916
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