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Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody
T. Jirásek, Š. Cipro, A. Musilová, M. Kubecová, V. Mandys
Jazyk angličtina Země Indie
NLK
Free Medical Journals
od 2006
Freely Accessible Science Journals
od 2006
MedKnow Publications
od 2006
Open Access Digital Library
od 2003-01-01
Medline Complete (EBSCOhost)
od 2008-02-01
- MeSH
- dospělí MeSH
- financování organizované MeSH
- imunohistochemie MeSH
- kolorektální nádory metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- monoklonální protilátky metabolismus MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tubulin metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
BACKGROUND & OBJECTIVE: Expression of class III beta-tubulin represents newly discovered marker of resistance to taxol-based chemotherapy in a wide spectra of carcinomas. However, very little is known about its expression in colorectal carcinomas. This study was done to determine class III beta-tubulin expression in a large series of colonic carcinomas, covering tumours with different degree of differentiation in order to evaluate its prospective significance in resistance to taxol-based chemotherapeutics and to compare the immunostaining profile of two widely used monoclonal antibodies, TU-20 and TuJ-1
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- $a Department of Pathology, 3rd Faculty of Medicine, Charles University Prague, Czech Republic. tjirasek@fnkv.cz
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- $a BACKGROUND & OBJECTIVE: Expression of class III beta-tubulin represents newly discovered marker of resistance to taxol-based chemotherapy in a wide spectra of carcinomas. However, very little is known about its expression in colorectal carcinomas. This study was done to determine class III beta-tubulin expression in a large series of colonic carcinomas, covering tumours with different degree of differentiation in order to evaluate its prospective significance in resistance to taxol-based chemotherapeutics and to compare the immunostaining profile of two widely used monoclonal antibodies, TU-20 and TuJ-1
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