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Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination
J. Novotný, P. Kovaříková, M. Novotný, B. Janůšová, A. Hrabálek, K. Vávrová
Pharmaceutical research.
2009 ;
26 (4) :
811-821.
Language English Country United States
Persistent link
https://www.medvik.cz/link/bmc11009601
Online
NLK
ProQuest Central
from 1997-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1997-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-01-01 to 1 year ago
- MeSH
- Adenine analogs & derivatives metabolism MeSH
- Alanine analogs & derivatives administration & dosage pharmacology chemical synthesis MeSH
- Administration, Cutaneous MeSH
- Time Factors MeSH
- Electric Impedance MeSH
- Esterases metabolism MeSH
- Chemistry, Pharmaceutical MeSH
- Financing, Organized MeSH
- Halogenation MeSH
- Hydrocortisone metabolism MeSH
- Hydrolysis MeSH
- Indomethacin metabolism MeSH
- Isomerism MeSH
- Caproates administration & dosage pharmacology chemical synthesis MeSH
- Skin Absorption drug effects MeSH
- Skin metabolism drug effects MeSH
- Methylamines administration & dosage pharmacology chemical synthesis MeSH
- Molecular Structure MeSH
- Drug Carriers MeSH
- Organophosphonates metabolism MeSH
- Swine MeSH
- Drug Compounding MeSH
- Drug Stability MeSH
- Theophylline metabolism MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
PURPOSE: Series of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking chain length and polyfluorination were investigated.
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- $a Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Faculty of Pharmacy Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic.
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- $a PURPOSE: Series of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking chain length and polyfluorination were investigated.
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