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Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery
H. Klamová, M. Marková, J. Moravcová, M. Šišková, P. Cetkovský, K. Poláková-Machová
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
Grant support
NR8758
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy therapy MeSH
- Adult MeSH
- Interferons therapeutic use MeSH
- Leukapheresis MeSH
- Humans MeSH
- Pregnancy Complications, Neoplastic drug therapy therapy MeSH
- Piperazines therapeutic use MeSH
- Antineoplastic Agents therapeutic use MeSH
- Pyrimidines therapeutic use MeSH
- Pregnancy MeSH
- Thiazoles therapeutic use MeSH
- Delivery, Obstetric MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Here we report response to treatment of chronic myeloid leukemia (CML) of five pregnant women during and after pregnancy. CML was diagnosed during pregnancy in three patients. Pregnancy was confirmed during CML in two patients: in one in the 21st week of pregnancy while on imatinib, in another in the 12th week during the interferon treatment. Interferon with leukapheresis when needed was applied in the 2nd and 3rd trimester. All patients except one achieved complete hematological response during pregnancy. After delivery four patients achieved partial cytogenetic response on imatinib and two patients achieved major molecular response after crossover to dasatinib.
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