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Application of HILIC stationary phase to determination of dimethindene maleate in topical gel
L. Matysová, L. Havlíková, R. Hájková, A. Krivda, P. Solich
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Histamine H1 Antagonists analysis administration & dosage MeSH
- Administration, Topical MeSH
- Dimethindene analysis administration & dosage MeSH
- Gels MeSH
- Reference Standards MeSH
- Spectrophotometry, Ultraviolet MeSH
- Chromatography, High Pressure Liquid methods MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
A novel high performance liquid chromatography method for the determination of dimethindene maleate in pharmaceutical gel using hydrophilic interaction liquid chromatography (HILIC) with UV detection was developed and validated. Following optimal conditions for the analysis of dimethindene maleate were used: analytical column SeQuant ZIC-HILIC (50mmx2.1mm, 5microm), and mobile phase consisted of a mixture of acetonitrile and aqueous solution of acetic acid (25mM) and ammonium acetate (2.5mM) (87.5:12.5, v:v). The analysis time was less than 3min at a flow rate of 0.3mlmin(-1). UV detection was performed at 258nm. The method was validated and system suitability parameters were evaluated. The method is suitable for application for routine determination of dimethindene maleate in topical pharmaceutical preparation.
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- $a Matysová, Ludmila, $d 1967- $7 stk2007393930
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- $a Application of HILIC stationary phase to determination of dimethindene maleate in topical gel / $c L. Matysová, L. Havlíková, R. Hájková, A. Krivda, P. Solich
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- $a Department of Analytical Chemistry, Charles University, Hradec Kralove, Czech Republic.
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- $a A novel high performance liquid chromatography method for the determination of dimethindene maleate in pharmaceutical gel using hydrophilic interaction liquid chromatography (HILIC) with UV detection was developed and validated. Following optimal conditions for the analysis of dimethindene maleate were used: analytical column SeQuant ZIC-HILIC (50mmx2.1mm, 5microm), and mobile phase consisted of a mixture of acetonitrile and aqueous solution of acetic acid (25mM) and ammonium acetate (2.5mM) (87.5:12.5, v:v). The analysis time was less than 3min at a flow rate of 0.3mlmin(-1). UV detection was performed at 258nm. The method was validated and system suitability parameters were evaluated. The method is suitable for application for routine determination of dimethindene maleate in topical pharmaceutical preparation.
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- $t Journal of Pharmaceutical & Biomedical Analysis $g Roč. 50, č. 1 (2009), s. 23-26 $w MED00002894
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