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Role of GABA(B) receptor agonist baclofen in acute pain modulation during the early postnatal period
M. Franěk, Š. Vaculín
Jazyk angličtina Země Švýcarsko
Typ dokumentu práce podpořená grantem
NLK
Karger Journals
od 1970 do 2009
ProQuest Central
od 1998-01-01 do 2015-11-30
Medline Complete (EBSCOhost)
od 1998-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1998-01-01 do 2015-11-30
Health & Medicine (ProQuest)
od 1998-01-01 do 2015-11-30
- MeSH
- agonisté receptorů GABA-B MeSH
- akutní nemoc MeSH
- baklofen aplikace a dávkování farmakologie MeSH
- bolest farmakoterapie patofyziologie MeSH
- GABA agonisté aplikace a dávkování farmakologie MeSH
- krysa rodu rattus MeSH
- modely nemocí na zvířatech MeSH
- pohybová aktivita účinky léků MeSH
- potkani Wistar MeSH
- věkové faktory MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
BACKGROUND: Baclofen, a specific GABA(B) receptor agonist, is used to treat spasticity and its off-label use includes the treatment of pain. The aim of this study was to show the role of baclofen in acute pain modulation during the early postnatal period. METHODS: Baclofen was tested in 2 doses (1 and 5 mg/kg) in 3 age groups (postnatal days 7, 16 and 21) in order to assess its effect on acute nociception and motor co ordination in rat pups. Pain was evaluated by measurement of paw/tail withdrawal latencies, and motor coordination by age-relevant tests. RESULTS: Although baclofen impaired motor function in all age groups, no changes in paw withdrawal latencies were observed. On the other hand, baclofen significantly increased tail withdrawal latencies of all groups. CONCLUSION: It is concluded that the GABA(B) system is functionally matured in the early postnatal period and plays a similar, but not the same, role as in adulthood.
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- $a Department of Normal, Pathological and Clinical Physiology, Charles University, Prague, Czech Republic. franek@lf3.cuni.cz
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- $a BACKGROUND: Baclofen, a specific GABA(B) receptor agonist, is used to treat spasticity and its off-label use includes the treatment of pain. The aim of this study was to show the role of baclofen in acute pain modulation during the early postnatal period. METHODS: Baclofen was tested in 2 doses (1 and 5 mg/kg) in 3 age groups (postnatal days 7, 16 and 21) in order to assess its effect on acute nociception and motor co ordination in rat pups. Pain was evaluated by measurement of paw/tail withdrawal latencies, and motor coordination by age-relevant tests. RESULTS: Although baclofen impaired motor function in all age groups, no changes in paw withdrawal latencies were observed. On the other hand, baclofen significantly increased tail withdrawal latencies of all groups. CONCLUSION: It is concluded that the GABA(B) system is functionally matured in the early postnatal period and plays a similar, but not the same, role as in adulthood.
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