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Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma

Martin Beránek, Monika Drastíková, Simona Paulíková, Igor Sirák, Milan Vošmik, Jiří Petera

. 2011 ; 54 (3) : 111-116.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc12000518

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Clinical oncologists have been focusing their efforts on attempting to define risk groups of patients with unusual biological reactions to the recommended therapy regimens using molecular biology techniques. The aims of our study were: (i) to find a design and validate a method for fast and reliable analysis of the D1853N (5557G>A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; (ii) to use side-directed mutagenesis to generate ATM 5557A-positive DNA (reference ATM5557A DNA); and (iii) to analyze a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (15%). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation probably does not differ from the prevalence common in Caucasians. A larger population study should confirm these preliminary results.

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Literatura

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$a Clinical oncologists have been focusing their efforts on attempting to define risk groups of patients with unusual biological reactions to the recommended therapy regimens using molecular biology techniques. The aims of our study were: (i) to find a design and validate a method for fast and reliable analysis of the D1853N (5557G>A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; (ii) to use side-directed mutagenesis to generate ATM 5557A-positive DNA (reference ATM5557A DNA); and (iii) to analyze a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (15%). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation probably does not differ from the prevalence common in Caucasians. A larger population study should confirm these preliminary results.
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$a Drastíková, Monika $7 xx0321911 $u Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Králové
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$a Paulíková, Simona $7 xx0245927 $u Department of Clinical Oncology, Faculty of Medicine and University Hospital, Hradec Králové
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$a Sirák, Igor $7 xx0135409 $u Department of Clinical Oncology, Faculty of Medicine and University Hospital, Hradec Králové
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