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Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population
K. Rašlová, M. Dobiášová, J. A. Hubáček, D. Bencová, D. Siváková, Z. Danková, J. Franeková, A. Jabor, J. Gašparovič, B. Vohnout
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
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- MeSH
- Adult MeSH
- Esterification MeSH
- Extracellular Matrix Proteins genetics MeSH
- Genetic Predisposition to Disease epidemiology genetics MeSH
- Cholesterol, HDL blood MeSH
- Risk Assessment MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Humans MeSH
- Coronary Artery Disease epidemiology genetics blood MeSH
- Prevalence MeSH
- Pyrophosphatases genetics MeSH
- Risk Factors MeSH
- Statistics as Topic MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Slovakia MeSH
We assessed association between novel biomarkers of cardiovascular disease and conventional factors in 40 years old subjects (208 men and 266 women) from the general population of Slovakia. FERHDL (cholesterol esterification rate in HDL plasma), AIP – Atherogenic Index of Plasma [Log(TG/HDL-C)] as markers of lipoprotein particle size, and CILP2, FTO and MLXIPL polymorphisms, were examined in relation to biomarkers and conventional risk factors. Univariate analyses confirmed correlation between AIP, FERHDL and the most of measured parameters. Relations between AIP and CILP2, FTO and MLXIPL were not significant. However, CILP2 was significantly related to FERHDL in both genders. In multivariate analysis BMI was the strongest correlate of AIP levels. In a model where AIP was omitted, TG levels explained 43 % of the FERHDL variability in men, while in women HDL-C was the major determinant (42 %). In conclusions, FERHDL and AIP related to the known markers of cardiovascular risk provide means to express their subtle interactions by one number. Our novel finding of association between CILP2 polymorphism and FERHDL supports its role in lipid metabolism.
Department of Anthropology Faculty of Sciences Comenius University Bratislava
Department of Laboratory Methods Institute for Clinical and Experimental Medicine Prague
Institute of Physiology Academy of Sciences of the Czech Republic Prague
National Reference Centre for Familial Hyperlipoproteinemias Slovak Medical University Bratislava
References provided by Crossref.org
Obsahuje 5 tabulek
Bibliography, etc.Literatura
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- $a We assessed association between novel biomarkers of cardiovascular disease and conventional factors in 40 years old subjects (208 men and 266 women) from the general population of Slovakia. FERHDL (cholesterol esterification rate in HDL plasma), AIP – Atherogenic Index of Plasma [Log(TG/HDL-C)] as markers of lipoprotein particle size, and CILP2, FTO and MLXIPL polymorphisms, were examined in relation to biomarkers and conventional risk factors. Univariate analyses confirmed correlation between AIP, FERHDL and the most of measured parameters. Relations between AIP and CILP2, FTO and MLXIPL were not significant. However, CILP2 was significantly related to FERHDL in both genders. In multivariate analysis BMI was the strongest correlate of AIP levels. In a model where AIP was omitted, TG levels explained 43 % of the FERHDL variability in men, while in women HDL-C was the major determinant (42 %). In conclusions, FERHDL and AIP related to the known markers of cardiovascular risk provide means to express their subtle interactions by one number. Our novel finding of association between CILP2 polymorphism and FERHDL supports its role in lipid metabolism.
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