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Measuring diffusion parameters in the brain: comparing the real-time iontophoretic method and diffusion-weighted magnetic resonance
I Vorisek, E Sykova
Jazyk angličtina Země Velká Británie
Typ dokumentu práce podpořená grantem, přehledy
NLK
Medline Complete (EBSCOhost)
od 2006-01-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1889-01-01 do 2012-12-31
- MeSH
- iontoforéza MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
The extracellular space (ECS) diffusion parameters influence the movement of ions, neuroactive substances, hormones and metabolites in the nervous tissue. They also affect extrasynaptic transmission, a mode of signal transmission dependent solely on diffusion. This review compares in detail two methods for studying diffusion in the brain: the real-time iontophoretic tetramethylammonium method for ECS volume fraction and tortuosity measurements and diffusion weighted-magnetic resonance imaging for measuring the apparent diffusion coefficient of water. The results obtained using both methods under physiological conditions (post-natal development, ageing) or in pathologies (brain injury, ischaemia) and their similarities and differences are discussed.
Citace poskytuje Crossref.org
Literatura.
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