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Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
JZ Karasova, J Bajgar, D Jun, R Pavlikova, K Kuca
Language English Country United States
Document type Research Support, Non-U.S. Gov't
NLK
Medline Complete (EBSCOhost)
from 2006-08-01 to 1 year ago
- MeSH
- Acetylcholinesterase blood MeSH
- Diaphragm enzymology drug effects MeSH
- Time Factors MeSH
- Behavior, Animal drug effects MeSH
- Liver enzymology drug effects MeSH
- Rats MeSH
- Lethal Dose 50 MeSH
- Brain enzymology drug effects MeSH
- Organothiophosphorus Compounds toxicity MeSH
- Rats, Wistar MeSH
- Tissue Distribution drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agents--Russian VX (RVX;N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD(50) dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only by 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 35% and 15% at 30 min. While AChE and BChE activities were reduced only about 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potently inhibits ChE outside the central nervous system.
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