• Je něco špatně v tomto záznamu ?

Synthesis and biological activity of desmethoxy analogues of coruscanone A

L. Tichotová, E. Matoušová, M. Spulák, J. Kuneš, I. Votruba, V. Buchta, M. Pour

. 2011 ; 21 (20) : 6062-6066. [pub] 20110819

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12022135

A series of simple desmethoxy analogues of coruscanone A was prepared via a novel version of Ti(iPrO)(4)-mediated Knoevenagel condensation of cyclopentenedione with substituted benzaldehydes and cinnamic aldehydes, and the compounds were evaluated for antifungal activity and cytotoxicity. The most potent 2-benzylidenecyclopent-4-ene-1,3-dione possessed antifungal effect comparable to coruscanone A and a somewhat broader spectrum of activity against Candida species. The compound was also superior to fluconazole against several non-albicans Candida sp. Evaluation of the ability of the compound to influence cell proliferation using two different assays showed that 2-benzylidenecyclopent-4-ene-1,3-dione has lower cytotoxicity compared to the natural product.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12022135
003      
CZ-PrNML
005      
20151124154910.0
007      
ta
008      
120806s2011 xxk f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.bmcl.2011.08.059 $2 doi
035    __
$a (PubMed)21903391
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Vostatková, Lucie $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic $7 xx0230338
245    10
$a Synthesis and biological activity of desmethoxy analogues of coruscanone A / $c L. Tichotová, E. Matoušová, M. Spulák, J. Kuneš, I. Votruba, V. Buchta, M. Pour
520    9_
$a A series of simple desmethoxy analogues of coruscanone A was prepared via a novel version of Ti(iPrO)(4)-mediated Knoevenagel condensation of cyclopentenedione with substituted benzaldehydes and cinnamic aldehydes, and the compounds were evaluated for antifungal activity and cytotoxicity. The most potent 2-benzylidenecyclopent-4-ene-1,3-dione possessed antifungal effect comparable to coruscanone A and a somewhat broader spectrum of activity against Candida species. The compound was also superior to fluconazole against several non-albicans Candida sp. Evaluation of the ability of the compound to influence cell proliferation using two different assays showed that 2-benzylidenecyclopent-4-ene-1,3-dione has lower cytotoxicity compared to the natural product.
650    _2
$a gama-butyrolakton $x analogy a deriváty $x chemická syntéza $x chemie $x farmakologie $7 D015107
650    _2
$a zvířata $7 D000818
650    _2
$a antifungální látky $x chemická syntéza $x chemie $x farmakologie $7 D000935
650    _2
$a Candida $x účinky léků $7 D002175
650    _2
$a kandidóza $x farmakoterapie $7 D002177
650    _2
$a buněčné linie $7 D002460
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a cyklopentany $x chemická syntéza $x chemie $x farmakologie $7 D003517
650    _2
$a lidé $7 D006801
650    _2
$a myši $7 D051379
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a vztahy mezi strukturou a aktivitou $7 D013329
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Matoušová, Eliška $7 _AN026127 $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic
700    1_
$a Špulák, Marcel $7 xx0248693 $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic
700    1_
$a Kuneš, Jiří, $d 1965- $7 xx0105105 $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic
700    1_
$a Votruba, Ivan, $d 1942- $7 xx0030600 $u Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, CZ-166 10 Prague 6, Czech Republic
700    1_
$a Buchta, Vladimír, $d 1960- $7 mzk2002156768 $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic; Department of Clinical Microbiology, University Hospital and Charles University, Faculty of Medicine, Sokolská 581, CZ-500 12, Hradec Králové, Czech Republic
700    1_
$a Pour, Milan, $d 1966- $7 jn20010310057 $u Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic
773    0_
$w MED00000770 $t Bioorganic & medicinal chemistry letters $x 1464-3405 $g Roč. 21, č. 20 (2011), s. 6062-6066
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21903391 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120806 $b ABA008
991    __
$a 20151124154938 $b ABA008
999    __
$a ok $b bmc $g 944048 $s 779432
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 21 $c 20 $d 6062-6066 $e 20110819 $i 1464-3405 $m Bioorganic & medicinal chemistry letters $n Bioorg Med Chem Lett $x MED00000770
LZP    __
$b NLK111 $a Pubmed-20120806/12/01

Najít záznam

Citační ukazatele

Možnosti archivace