• Something wrong with this record ?

Relationship between the 17q21 locus and adult asthma in a Czech population

B. Hrdlickova, LI. Holla

. 2011 ; 72 (10) : 921-925. [pub] 20110801

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12022304

Several whole-genome association studies have shown a significant link between childhood asthma and the 17q12 chromosome region. We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in a Czech Caucasian population of adults. We conducted a case-control association study comprising 668 unrelated subjects (337 asthmatic and 331 control subjects). Four selected SNPs (rs17608925, rs12603332, rs8076131, and rs3169572) were genotyped using the TaqMan SNP Genotyping Assays. The single locus analysis showed only a borderline association between rs3169572 variant and asthma (p = 0.030, p(corr) > 0.05). However, seven different haplotypes were identified; among them, the TTAA haplotype was marginally associated with asthma (p = 0.045, p(corr) > 0.05) and TCAG haplotype was significantly associated with asthma in males (p = 0.009, p(corr) < 0.05, odds ratio = 1.48, 95% confidence interval = 1.10-2.00). In addition, associations between the ORMDL3 genotypes and the total IgE level (p = 0.05, p(corr) > 0.05) and hypersensitivity to the pollen (p = 0.007, p(corr) < 0.05) were established. However, no relationship between ORMDL3 SNPs and the pulmonary functions was found (p > 0.05). These findings suggest that the genetic variability in the 17q21 region may be one of the risk factors also for adult asthma, especially in male individuals.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12022304
003      
CZ-PrNML
005      
20160405140901.0
007      
ta
008      
120806s2011 xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.humimm.2011.07.309 $2 doi
035    __
$a (PubMed)21843571
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hrdličková, Barbara $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno; Department of Surgery, University Hospital Brno-Bohunice, Brno, Czech Republic $7 xx0230806
245    10
$a Relationship between the 17q21 locus and adult asthma in a Czech population / $c B. Hrdlickova, LI. Holla
520    9_
$a Several whole-genome association studies have shown a significant link between childhood asthma and the 17q12 chromosome region. We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in a Czech Caucasian population of adults. We conducted a case-control association study comprising 668 unrelated subjects (337 asthmatic and 331 control subjects). Four selected SNPs (rs17608925, rs12603332, rs8076131, and rs3169572) were genotyped using the TaqMan SNP Genotyping Assays. The single locus analysis showed only a borderline association between rs3169572 variant and asthma (p = 0.030, p(corr) > 0.05). However, seven different haplotypes were identified; among them, the TTAA haplotype was marginally associated with asthma (p = 0.045, p(corr) > 0.05) and TCAG haplotype was significantly associated with asthma in males (p = 0.009, p(corr) < 0.05, odds ratio = 1.48, 95% confidence interval = 1.10-2.00). In addition, associations between the ORMDL3 genotypes and the total IgE level (p = 0.05, p(corr) > 0.05) and hypersensitivity to the pollen (p = 0.007, p(corr) < 0.05) were established. However, no relationship between ORMDL3 SNPs and the pulmonary functions was found (p > 0.05). These findings suggest that the genetic variability in the 17q21 region may be one of the risk factors also for adult asthma, especially in male individuals.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a bronchiální astma $x epidemiologie $x genetika $x imunologie $7 D001249
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a lidské chromozomy, pár 17 $x chemie $x genetika $7 D002886
650    _2
$a běloši $7 D044465
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a frekvence genu $7 D005787
650    _2
$a genetické lokusy $7 D056426
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a genotyp $7 D005838
650    _2
$a haplotypy $7 D006239
650    _2
$a lidé $7 D006801
650    _2
$a časná přecitlivělost $x epidemiologie $x genetika $x imunologie $7 D006969
650    _2
$a imunoglobulin E $x biosyntéza $x imunologie $7 D007073
650    _2
$a vazebná nerovnováha $7 D015810
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a membránové proteiny $x genetika $7 D008565
650    _2
$a lidé středního věku $7 D008875
650    _2
$a odds ratio $7 D016017
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a rizikové faktory $7 D012307
651    _2
$a Česká republika $7 D018153
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Izakovičová Hollá, Lydie, $d 1971- $7 nlk19990074300 $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
773    0_
$w MED00002076 $t Human immunology $x 1879-1166 $g Roč. 72, č. 10 (2011), s. 921-925
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21843571 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120806 $b ABA008
991    __
$a 20160405140937 $b ABA008
999    __
$a ok $b bmc $g 944217 $s 779601
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 72 $c 10 $d 921-925 $e 20110801 $i 1879-1166 $m Human immunology $n Hum Immunol $x MED00002076
LZP    __
$b NLK111 $a Pubmed-20120806/12/01

Find record

Citation metrics

Archiving options