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A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study
I. Skalský, O. Szárszoi, E. Filová, M. Pařízek, A. Lytvynets, J. Malušková, A. Lodererová, E. Brynda, V. Lisá, Z. Burdíková, M. Capek, J. Pirk, L. Bačáková,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
22387280
DOI
10.1016/j.ijpharm.2012.02.023
Knihovny.cz E-zdroje
- MeSH
- chirurgické síťky MeSH
- činčila MeSH
- fixace tkání MeSH
- hyperplazie patologie MeSH
- imunohistochemie MeSH
- imunosupresiva aplikace a dávkování terapeutické užití MeSH
- králíci MeSH
- léky implantované MeSH
- okluze cévního štěpu patologie prevence a kontrola MeSH
- počet buněk MeSH
- polyestery MeSH
- proliferace buněk MeSH
- proliferační antigen buněčného jádra metabolismus MeSH
- sirolimus aplikace a dávkování terapeutické užití MeSH
- svaly hladké cévní účinky léků MeSH
- tunica intima patologie MeSH
- tunica media patologie MeSH
- vény transplantace MeSH
- zalévání tkání do parafínu MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implanted v. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histological staining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 ± 11% or 73 ± 8% after 3 weeks, and by 73 ± 9% or 59 ± 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 ± 9% and 20 ± 12% after 3 and 6 weeks. The thickness of the intima-media complex in grafts with sirolimus-releasing meshes decreased by 60 ± 6% and 30 ± 13% in comparison with pure PES meshes, after 3 and 6 weeks, respectively. A periadventitial polyester mesh releasing sirolimus has the potential to become an effective device in preventing vein graft restenosis.
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- $a The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implanted v. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histological staining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 ± 11% or 73 ± 8% after 3 weeks, and by 73 ± 9% or 59 ± 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 ± 9% and 20 ± 12% after 3 and 6 weeks. The thickness of the intima-media complex in grafts with sirolimus-releasing meshes decreased by 60 ± 6% and 30 ± 13% in comparison with pure PES meshes, after 3 and 6 weeks, respectively. A periadventitial polyester mesh releasing sirolimus has the potential to become an effective device in preventing vein graft restenosis.
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