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DNA interstrand cross-linking agents and their chemotherapeutic potential
L. Brulikova, J. Hlavac, P. Hradil,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Alkaloids chemistry therapeutic use MeSH
- Anthraquinones chemistry therapeutic use MeSH
- Azepines chemistry therapeutic use MeSH
- Aziridines chemistry therapeutic use MeSH
- DNA chemistry metabolism MeSH
- Coordination Complexes chemistry therapeutic use MeSH
- Humans MeSH
- Mechlorethamine chemistry therapeutic use MeSH
- Neoplasms drug therapy MeSH
- DNA Repair MeSH
- Antineoplastic Agents chemistry therapeutic use MeSH
- Cross-Linking Reagents chemistry therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.
References provided by Crossref.org
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- $a DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.
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