Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

D. Smajs, SJ. Norris, GM. Weinstock,

. 2012 ; 12 (2) : 191-202.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc12024163

Grantová podpora
NT11159 MZ0 CEP - Centrální evidence projektů

Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pallidum treponemes revealed genes with potential involvement in human infectivity, whereas comparisons between pallidum and pertenue treponemes identified genes possibly involved in the high invasivity of syphilis treponemes. Genetic variability within syphilis strains is considered as the basis of syphilis molecular epidemiology with potential to detect more virulent strains, whereas genetic variability within a single strain is related to its ability to elude the immune system of the host. Genome analyses also shed light on treponemal evolution and on chromosomal targets for molecular diagnostics of treponemal infections.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12024163
003      
CZ-PrNML
005      
20170418101709.0
007      
ta
008      
120815s2012 ne f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.meegid.2011.12.001 $2 doi
035    __
$a (PubMed)22198325
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Šmajs, David, $u Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic. dsmajs@med.muni.cz $d 1969- $7 xx0061318
245    10
$a Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws / $c D. Smajs, SJ. Norris, GM. Weinstock,
520    9_
$a Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pallidum treponemes revealed genes with potential involvement in human infectivity, whereas comparisons between pallidum and pertenue treponemes identified genes possibly involved in the high invasivity of syphilis treponemes. Genetic variability within syphilis strains is considered as the basis of syphilis molecular epidemiology with potential to detect more virulent strains, whereas genetic variability within a single strain is related to its ability to elude the immune system of the host. Genome analyses also shed light on treponemal evolution and on chromosomal targets for molecular diagnostics of treponemal infections.
650    _2
$a zvířata $7 D000818
650    _2
$a molekulární evoluce $7 D019143
650    _2
$a genetická variace $7 D014644
650    _2
$a lidé $7 D006801
650    _2
$a molekulární typizace $7 D058889
650    _2
$a králíci $7 D011817
650    _2
$a syfilis $x diagnóza $x mikrobiologie $7 D013587
650    _2
$a Treponema pallidum $x klasifikace $x genetika $x patogenita $7 D014210
650    _2
$a faktory virulence $7 D037521
650    _2
$a frambézie $x diagnóza $x mikrobiologie $7 D015001
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Norris, Steven J
700    1_
$a Weinstock, George M
773    0_
$w MED00008609 $t Infection, genetics and evolution journal of molecular epidemiology and evolutionary genetics in infectious diseases $x 1567-7257 $g Roč. 12, č. 2 (2012), s. 191-202
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22198325 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120815 $b ABA008
991    __
$a 20170418102017 $b ABA008
999    __
$a ok $b bmc $g 946311 $s 781491
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 12 $c 2 $d 191-202 $i 1567-7257 $m Infection, genetics and evolution $n Infect Genet Evol $x MED00008609
GRA    __
$a NT11159 $p MZ0
LZP    __
$a Pubmed-20120815/12/02

Najít záznam

Citační ukazatele

Možnosti archivace