-
Something wrong with this record ?
Selective increase in blood dendritic cell antigen-3-positive dendritic cells in bronchoalveolar lavage fluid in allergic patients
J. Kayserova, I. Zentsova-Jaresova, V. Budinsky, D. Rozkova, J. Kopecka, E. Vernerova, P. Pohunek, V. Skalicka, R. Spisek, A. Sediva,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1997 to 1 year ago
Medline Complete (EBSCOhost)
from 1972-01-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
Wiley Free Content
from 1997 to 1 year ago
- MeSH
- Asthma blood immunology MeSH
- Bronchoalveolar Lavage Fluid cytology immunology MeSH
- Dendritic Cells cytology immunology MeSH
- Child MeSH
- Adult MeSH
- GPI-Linked Proteins blood immunology MeSH
- Immunophenotyping methods MeSH
- Lectins, C-Type blood immunology MeSH
- Humans MeSH
- Cell Adhesion Molecules blood immunology MeSH
- Statistics, Nonparametric MeSH
- Lung cytology immunology MeSH
- Flow Cytometry MeSH
- Receptors, Cell Surface blood immunology MeSH
- Receptors, IgG blood immunology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and in controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 positivity or negativity] were detected in both tested compartments. We further evaluated the expression of C-type lectins [mannose receptor (MR), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of asthma. Interestingly, we found a selective increase in the frequency of myeloid DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a novel characteristic to BAL analysis in allergic patients.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12024334
- 003
- CZ-PrNML
- 005
- 20121210111849.0
- 007
- ta
- 008
- 120815s2012 enk f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1111/j.1365-3083.2011.02649.x $2 doi
- 035 __
- $a (PubMed)21988460
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Kayserova, J $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
- 245 10
- $a Selective increase in blood dendritic cell antigen-3-positive dendritic cells in bronchoalveolar lavage fluid in allergic patients / $c J. Kayserova, I. Zentsova-Jaresova, V. Budinsky, D. Rozkova, J. Kopecka, E. Vernerova, P. Pohunek, V. Skalicka, R. Spisek, A. Sediva,
- 520 9_
- $a Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and in controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 positivity or negativity] were detected in both tested compartments. We further evaluated the expression of C-type lectins [mannose receptor (MR), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of asthma. Interestingly, we found a selective increase in the frequency of myeloid DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a novel characteristic to BAL analysis in allergic patients.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a bronchiální astma $x krev $x imunologie $7 D001249
- 650 _2
- $a bronchoalveolární lavážní tekutina $x cytologie $x imunologie $7 D001992
- 650 _2
- $a molekuly buněčné adheze $x krev $x imunologie $7 D015815
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a dendritické buňky $x cytologie $x imunologie $7 D003713
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a průtoková cytometrie $7 D005434
- 650 _2
- $a GPI-vázané proteiny $x krev $x imunologie $7 D058851
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunofenotypizace $x metody $7 D016130
- 650 _2
- $a lektiny typu C $x krev $x imunologie $7 D037181
- 650 _2
- $a plíce $x cytologie $x imunologie $7 D008168
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a receptory buněčného povrchu $x krev $x imunologie $7 D011956
- 650 _2
- $a receptory IgG $x krev $x imunologie $7 D017452
- 650 _2
- $a neparametrická statistika $7 D018709
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Zentsova-Jaresova, I
- 700 1_
- $a Budinsky, V
- 700 1_
- $a Rozkova, D
- 700 1_
- $a Kopecka, J
- 700 1_
- $a Vernerova, E
- 700 1_
- $a Pohunek, P
- 700 1_
- $a Skalicka, V
- 700 1_
- $a Spisek, R
- 700 1_
- $a Sediva, A
- 773 0_
- $w MED00010600 $t Scandinavian journal of immunology $x 1365-3083 $g Roč. 75, č. 3 (2012), s. 305-13
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/21988460 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m
- 990 __
- $a 20120815 $b ABA008
- 991 __
- $a 20121210111926 $b ABA008
- 999 __
- $a ok $b bmc $g 946482 $s 781662
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 75 $c 3 $d 305-13 $i 1365-3083 $m Scandinavian journal of immunology $n Scand J Immunol $x MED00010600
- LZP __
- $a Pubmed-20120815/12/02
