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The diffusion parameters of the extracellular space are altered in focal cortical dysplasias
L. Vargova, A. Homola, M. Cicanic, K. Kuncova, P. Krsek, P. Marusic, E. Sykova, J. Zamecnik
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NS9915
MZ0
CEP - Centrální evidence projektů
- MeSH
- dítě MeSH
- dospělí MeSH
- epilepsie patologie MeSH
- extracelulární prostor fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- malformace mozkové kůry patologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozková kůra abnormality patologie MeSH
- neurony patologie fyziologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Most hypotheses concerning the mechanisms underlying seizure activity in focal cortical dysplasia (FCD) are based on alterations in synaptic transmission and glial dysfunction. However, neurons may also communicate by extrasynaptic transmission, which was recently found to affect epileptiform activity under experimental conditions and which is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). The ECS diffusion parameters were therefore determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients. The obtained values of the extracellular space volume fraction and tortuosity were then correlated with the histologicaly assessed type of cortical malformation (FCD type I or II). While the extracellular volume remained unchanged (FCD I) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion, which might be another factor contributing to the epileptogenicity of FCD.
Citace poskytuje Crossref.org
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- $a Vargová, Lýdia $7 xx0115035 $u Department of Neuroscience and Center for Cell Therapy and Tissue Repair, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Department of Neuroscience, Institute of Experimental Medicine, AS CR, Prague, Czech Republic
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- $a The diffusion parameters of the extracellular space are altered in focal cortical dysplasias / $c L. Vargova, A. Homola, M. Cicanic, K. Kuncova, P. Krsek, P. Marusic, E. Sykova, J. Zamecnik
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- $a Most hypotheses concerning the mechanisms underlying seizure activity in focal cortical dysplasia (FCD) are based on alterations in synaptic transmission and glial dysfunction. However, neurons may also communicate by extrasynaptic transmission, which was recently found to affect epileptiform activity under experimental conditions and which is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). The ECS diffusion parameters were therefore determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients. The obtained values of the extracellular space volume fraction and tortuosity were then correlated with the histologicaly assessed type of cortical malformation (FCD type I or II). While the extracellular volume remained unchanged (FCD I) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion, which might be another factor contributing to the epileptogenicity of FCD.
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- $a Homola, Aleš $7 xx0278724 $u Department of Neuroscience and Center for Cell Therapy and Tissue Repair, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Department of Neuroscience, Institute of Experimental Medicine, AS CR, Prague, Czech Republic
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