Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies

J. Zivny, P. Klener jr., R. Pytlik, L. Andera

. 2010 ; 16 (1) : 11-33.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025139

Grantová podpora
NR8317 MZ0 CEP - Centrální evidence projektů
NR8930 MZ0 CEP - Centrální evidence projektů
NS10287 MZ0 CEP - Centrální evidence projektů

Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12025139
003      
CZ-PrNML
005      
20141105133452.0
007      
ta
008      
120816s2010 ne f 000 0#eng||
009      
AR
024    7_
$a 10.2174/138161210789941883 $2 doi
035    __
$a (PubMed)20214615
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Živný, Jan $7 xx0115576 $u Institute of Pathological Physiology, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic; Center of Experimental Hematology, First Faculty of Medicine, Charles University, Charles University in Prague, Czech Republic. jzivny@LF1.cuni.cz
245    14
$a The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies / $c J. Zivny, P. Klener jr., R. Pytlik, L. Andera
520    9_
$a Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article.
650    _2
$a zvířata $7 D000818
650    _2
$a protinádorové látky $x chemie $x terapeutické užití $7 D000970
650    _2
$a apoptóza $x účinky léků $x genetika $7 D017209
650    _2
$a proteiny regulující apoptózu $x metabolismus $7 D051017
650    _2
$a racionální návrh léčiv $7 D015195
650    _2
$a chemorezistence $7 D019008
650    _2
$a epigeneze genetická $x účinky léků $7 D044127
650    _2
$a regulace genové exprese u nádorů $x účinky léků $7 D015972
650    _2
$a hematologické nádory $x farmakoterapie $x genetika $x metabolismus $x patologie $7 D019337
650    _2
$a lidé $7 D006801
650    _2
$a signální transdukce $x účinky léků $7 D015398
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Klener, Pavel, $d 1937- $7 jk01060408 $u Institute of Pathological Physiology, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic; Center of Experimental Hematology, First Faculty of Medicine, Charles University, Charles University in Prague, Czech Republic; 1st Medical Department - Clinical Department of Haematology of First Faculty of Medicine and General Teaching Hospital, Charles University in Prague, Czech Republic
700    1_
$a Pytlík, Robert, $d 1967- $7 xx0061345 $u 1st Medical Department - Clinical Department of Haematology of First Faculty of Medicine and General Teaching Hospital, Charles University in Prague, Czech Republic
700    1_
$a Anděra, Ladislav $7 xx0140308 $u Laboratory of Cell Signaling and Apoptosis, Institute of Molecular Genetics, Czech Academy of Science, Prague, Czech Republic
773    0_
$w MED00007893 $t Current pharmaceutical design $x 1873-4286 $g Roč. 16, č. 1 (2010), s. 11-33
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20214615 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20141105133500 $b ABA008
999    __
$a ok $b bmc $g 947181 $s 782485
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 16 $c 1 $d 11-33 $i 1873-4286 $m Current pharmaceutical design $n Curr Pharm Des $x MED00007893
GRA    __
$a NR8317 $p MZ0
GRA    __
$a NR8930 $p MZ0
GRA    __
$a NS10287 $p MZ0
LZP    __
$a Pubmed-20120816/10/02

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace