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Salicylanilide carbamates: antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains

Juana M. Férriz, Kateřina Vávrová, Filip Kunc, Aleš Imramovský, Jiřina Stolaříková, Eva Vavříková, Jarmila Vinšová

. 2010 ; 18 (3) : 1054-1061.

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12025311

Grant support
NS10367 MZ0 CEP Register

A series of 27 salicylanilide-based carbamates was prepared as a part of our ongoing search for new antituberculosis drugs. These compounds exhibited very good in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium and, in particular, against five multidrug-resistant strains, with MIC values between 0.5-2 micromol/L. Moreover, they displayed moderate toxicity against intestinal cells with the selectivity index being up to 96. Furthermore, acid stability and a half-life of 43h at pH 7.4 were shown. Thus, these novel salicylanilide derivatives are drug candidates which should be seriously consider for further screening.

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