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Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
A. Fialová, Z. Cimburek, G. Iezzi, J. Kopecký,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dendritické buňky virologie MeSH
- interleukin-6 metabolismus MeSH
- klíště virologie MeSH
- kultivované buňky MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- sliny fyziologie MeSH
- TNF-alfa metabolismus MeSH
- viry klíšťové encefalitidy patogenita MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
Citace poskytuje Crossref.org
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